ABCG2

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ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
References in periodicals archive ?
Analysis of SNPs in orthologs of known drug-resistance genes identified 3 nonsynonymous SNPs in the multidrug resistance protein 2 (mdr2) gene, 1 of which was in the ABC transporter domain, and 2 in the ABC transporter domain of ABC transporter C family member 2, present in the recrudescent strain (H2) but not the other strains (online Technical Appendix Table 7).
Identification of a New Biocontrol Gene in Trichodermaatroviride: The Role of an ABC Transporter Membrane Pump in the interaction with different plant-pathogenic fungi.
Among the human ABC transporter superfamily, ABCB1 (P-gp), ABCC1 (MRP1), and ABCG2 (BCRP), are widely recognized to be associated with cancer MDR (Szakacs et al.
In mammals, nearly 50 different ABC transporter proteins are known these are mostly expressed in the liver, intestine, kidney, and brain sites where natural toxic and waste products are removed by the body.
The ABC transporter structure and mechanism: perspectives on recent research.
Scientists have struggled with understanding how ABC transporter proteins work and communicate with other proteins.
Data from the present study revealed that the MICs of maximum number of isolates were affected in the presence of verapamil suggesting the importance of eflux pumps of ABC transporter family in oloxacin resistance in M.
Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum.
Gene expression analysis of selected genes in the liver and large intestine demonstrated increased levels of IL-10, Liver X Receptor (LXR), and ABC transporter G1.
Future studies that wish to assess the clinical benefit of an ABC inhibitor should ensure that patients express at least one ABC transporter.
2005, "Overexpression of an Arabidopsis thaliana ABC transporter confers kanamycin resistance to transgenic plants," Nat.
The segment which showed similarity was upstream from an ABC transporter (15) transmembrane domain (pfam 06472).