ABCG2

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ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
References in periodicals archive ?
Interestingly, 2',2'-difluorodeoxyuridine (dFdU), the major inactive metabolite of gemcitabine, is a substrate of ABC transporter [27].
The mRNA level of MDR1 (ABC transporter) was found to be 4-fold higher in R-strains which supported the observations for increased drug efflux.
In mammals, nearly 50 different ABC transporter proteins are known these are mostly expressed in the liver, intestine, kidney, and brain sites where natural toxic and waste products are removed by the body.
ABC transporter proteins act as cellular gatekeepers by retaining nutrients and expelling toxins from the cell.
Data from the present study revealed that the MICs of maximum number of isolates were affected in the presence of verapamil suggesting the importance of eflux pumps of ABC transporter family in oloxacin resistance in M.
Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum.
Gene expression analysis of selected genes in the liver and large intestine demonstrated increased levels of IL-10, Liver X Receptor (LXR), and ABC transporter G1.
Lapatinib may also regulate ABC transporter protein levels.
2005, "Overexpression of an Arabidopsis thaliana ABC transporter confers kanamycin resistance to transgenic plants," Nat.
Protein interactions and disease phenotypes in the ABC transporter superfamily.
Analysis of ABC transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.
According to the degradome sequencing results in our study, the ptf-miR157a/b was confirmed to target the ABC transporter B family member 19 (ABCB19), which plays an important role in basipetally long-distance auxin transport from the seedling apex to roots, resulting in auxin accumulation to increase formation of adventitious roots [30,31].