ABC genes

ABC genes

Genes that code for the ATP-binding cassette transporter proteins that carry compounds across biological membranes. Fourteen different ABC genes are known to be associated with human genetic diseases.
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It's a complex process that involves several membrane-bound drug transporters, such as P-glycoprotein (P-gp, MDR1) and multidrug resistance (MDR) transporters, encoded by the ABC genes.
Therefore, and because ABC genes are prone to be involved in human genetic disorders, ABC transporters are promising target molecules for the treatment of lipid disorders such as cardiovascular disease (13).