autoantibody

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autoantibody

 [aw″to-an´tĭ-bod″e]
an antibody formed in response to, and reacting against, an antigenic constituent of the individual's own tissues.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

au·to·an·ti·bod·y

(aw'tō-an'ti-bod-ē),
An antibody that occurs in response to antigenic constituents of the host's tissue (or "self antigen") and reacts with the inciting target tissue.
Farlex Partner Medical Dictionary © Farlex 2012

autoantibody

(ô′tō-ăn′tĭ-bŏd′ē)
n.
An antibody that reacts with the cells, tissues, or native proteins of the individual in which it is produced.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

autoantibody

Any antibody produced by an organism against one of its own—self-antigens.

Autoantibodies
Examples of autoantibodies and disease associations
• Anti-actin antibodies—coeliac disease.
• Anti-centromere antibodies—CREST syndrome.
• Anti-ganglioside antibodies—acute motor neuronal neuropathy.
• Antimitochondrial antibody—primary biliary cirrhosis.
• Anti-neutrophil cytoplasmic antibody—Wegener’s granulomatosis (in neutrophil cytoplasm).
• Anti-neutrophil cytoplasmic antibody—Churg-Strauss syndrome, microscopic polyangiitis, systemic vasculitides (perinuclear location).
• Anti-nuclear antibodies (e.g., anti-SSA/Ro)—systemic lupus erythematosus.
• Anti-signal recognition peptide—polymyositis.
• Anti-smooth muscle antibody—chronic autoimmune hepatitis.
• Anti-glomerular basement membrane antibodies.
• Anti-parietal cell antibodies, and others.
• Anti-nuclear antibodies (ANA).
• Anti-smooth muscle actin (SMA).
• Anti-liver-kidney-microsomal antibody (LKM), 2 types:
   - Anti-mitochondrial (AMA);
   - Perinuclear antineutrophil cytoplasmic (pANCA).
• Anti-soluble liver antigen (SLA), other autoantibodies.
• ANA and SMAs are known to be positive in AIH, PBC, PSC, HCV, HBV, HDV, NASH, drug-induced hepatitis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

autoantibody

Immunology Any antibody produced by an organism against one of its own–self antigens. See Antibody, Hashimoto's thyroiditis, Lupus erythematosus, Myasthenia gravis, Rheumatoid arthritis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

au·to·an·ti·body

(aw'tō-an'ti-bod-ē)
Antibody occurring in response to antigenic constituents of the host's tissue, and which reacts with the inciting tissue component.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

autoantibody

An antibody derived from the immune system, which then acts against body tissues or constituents.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Autoantibody

An antibody produced by the body in reaction to any of its own cells or cell products.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

au·to·an·ti·body

(aw'tō-an'ti-bod-ē)
Antibody occurring in response to antigenic constituents of the host's tissue, and which reacts with the inciting tissue component.
Medical Dictionary for the Dental Professions © Farlex 2012
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