A238L | definition of A238L by Medical dictionary
A238L A protein encoded by African swine fever virus, which is homologous to I-kappa-B, inhibiting binding of NF-kappa-B to DNA, blocking transcription of NF-kappa-B-dependent genes, and inhibiting synthesis of antiviral, pro-inflammatory cytokines IFN-alpha, TNF-alpha, and IL8 in infected macrophages. A238L also inhibits activation of transcription factor NF-AT, which controls expression of immunomodulatory proteins and pro-inflammatory cytokines.
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References in periodicals archive
The more divergent proteins include several with immunomodulatory functions, such as A238L, which varies in amino acid identity from 58.9% (Malawi Lil20/1) to 81.3% (Mkuzi) compared with Georgia 2007/1.
The A238L and KP177R protein sequences from the Georgia 2007/1 isolate cluster the same as the concatenated conserved 125 proteins, the EP402R protein sequence from the Georgia 2007/1 sequence clusters more closely with the Malawi Lil20/1 and Kenya 1950 isolates, and the EP153R protein sequence from the Georgia 2007/1 isolate clustered more closely with the Warthog isolate.
In the early stages of infection, the early viral protein A238L
inhibits NF-[kappa][beta] expression, but once the infection progresses the late viral protein A224L stimulates its expression (60).