These enzymes cause methylation of the A2058
residue, located in the conserved domain V of the 23S rRNA component of the 50S ribosomal subunit, which leads to cross resistance and the formation of the inducible phenotype (iMLSB) of the resistance pattern.
is a highly invasive cell line from a 43-year-old male patient with malignant melanoma.
These are genes related to the expression of this phenotype, making the modification in the binding target due to the methylation of residue A2058
, locatedin the V domain of 23s (Naimi et al., 2001; Pereira & Cunha, 2009).
The MDA-MB-231, MCF-7 (breast cancer), SIHA (cervix cancer) cells were purchased from the American Type Culture Collection (Manassas, VA) and melanoma cells (SK-Mel-28 and A2058
) were gently provided by Dr.
Human and rat melanoma cell lines were obtained from Bioresource Collection and Research Center (Taiwan): A375 (BCRC number 60039), A375.S2 (BCRC number 60263), A2058
(BCRC number 60240), and B16-F10 (BCRC number 60031).
Chiu et al., "Proteomic investigation of anti-tumor activities exerted by sinularin against A2058
melanoma cells," Electrophoresis, vol.
Human Melanoma A2058
Cell and Mouse B16-F10 Melanoma Cell Cultures.
Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058
Chen, "The correlation of in vitro mushroom tyrosinase activity with cellular tyrosinase activity and melanin formation in melanoma cells A2058
," Journal of Food and Drug Analysis, vol.
The assessment of the mt in cells conducted by the authors indicated that A2058
cells treated with dosages higher than 0.5 J cm-2 He-Ne laser irradiation at 633 nm exhibited a marked increase in mt.