AMBP

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AMBP

A gene on chromosome 9q32-q33 that encodes alpha-1-microglobulin/bikunin precursor protein, which is expressed in liver and secreted in plasma. Alpha-1-microglobulin belongs to the superfamily of lipocalin transport proteins and plays a role in regulating inflammation; bikunin belongs to the superfamily of Kunitz-type protease inhibitors and plays a key role in many physiological and pathological processes, by inhibiting trypsin, plasmin and lysosomal granulocytic elastase, as well as calcium oxalate crystallisation.
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A1M Pharma's drug candidate ROSgard - based on the bodily protein Alfa-1-Microglobulin - has been documented in several preclinical studies to counteract acute kidney damage caused by oxidative stress by protecting, cleaning and repairing damaged tissue.
The overall mean associations were seen both for the LMW protein A1M and the HMW protein albumin.
Calibration curves showed direct proportionality up to 40, 30, 5, and 60 mg/L on MA, A1M, B2M, and IgG, individually and respectively (Fig.
The remains of an Iron Age chariot, which have remained buried for 2,500 years and were unearthed by motorway builders constructing the new A1M at Ferrybridge, West Yorkshire An artist impression of an Iron Age chariot
In England, a man was killed when his lorry was toppled by gales on the A1 near Catterick, North Yorkshire, and a woman passenger was killed when a lorry was blown down an embankment on the A1M in County Durham.
Telling the jury about the flashing above the A1M, near Doncaster, South Yorkshire, she wept: "We would go for a drink and then he'd drive to the motorway bridges and walk with me to the middle.
To my knowledge, the A1M stops at Newcastle, having been two lanes through Durham, with only short stretches of dual carriageway up to the Scottish border.
The man's body was found as the vehicle was removed from the River Don, just off the A1M, near Doncaster, South Yorkshire Police said.
Sergeant Chris Headley from the Durham force said: "At 13.53 hours on Saturday, June 13, police have responded to several reports of an aircraft apparently in difficulty near to Junction 61 of the A1M. A light aircraft was located by the police helicopter having landed in a fields between Bowburn and Shincliffe to the west of the A1M.
Middlesbrough-born Josephine Smith, 84, from Greater Manchester, died in hospital five days after the two-vehicle smash on the A1M near Sedgefield on June 20 last year.
The woman was killed on the A1M north of Baldock in Hertfordshire.