alpha 1 antitrypsin

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alpha 1 antitrypsin

A 54 kD glycoprotein that inhibits proteolytic enzymes (proteases),trypsin, chymotrypsin, elastases in lysosomes, plasmin, thrombin, collagenase, and others. Serum A1AT increases nonspecifically during inflammation and is a so-called acute phase reactant.
Elevated A1AT Inflammation, liver injury, increased oestrogen, pregnancy, malignancy, corticosteroid therapy.
Reduced A1AT Heterozygous A1AT deficiency, emphysema, prematurity, protein-losing disorders.
Ref range 2–4 g/L.
References in periodicals archive ?
The license grants Intrexon Corporation with exclusivity to alpha 1-antitrypsin for the indications resulting from A1AT deficiency.
Some early reference materials for A1AT were based on inhibition of trypsin preparations that varied markedly in enzyme activity and, therefore, in the assigned values for A1AT.
In the value transfers to RPSP-4 and RPPHS, however, only A1AT and Hp showed differences related to antisera, and those differences were minimal--in the range of [+ or -] 2% (unpublished data).
The majority of analytes examined (albumin, ALP, AGP, A1AT, ALT, amylase, AST, C3, C4, ceruloplasmin, cholesterol, CK, chloride, CRP, iron, GGT, haptoglobin, HDL-C, IgA, IgG, IgM, LDH, STfR, total protein, transferrin, uric acid, and urea) showed marked individuality, with II values of <0.
G], between-subject/ interindividual biological CV; CALIPER, Canadian Laboratory Initiative on Paediatric Reference Intervals; A1AT, [alpha]-1 antitrypsin; AGP, [alpha]-1 acid glycoprotein; C3, complement component 3; CRP, C-reactive protein; STfR, soluble transferrin receptor; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK, creatine kinase; GGT, [gamma] glutamyl transferase; HDL-C, HDL cholesterol; LDH, lactate dehydrogenase; [CV.
3) describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach for determining both the phenotype and the A1AT concentration in a single assay, in contrast to the usual approach of running 2 independent assays involving different techniques.
A1AT is a relatively polymorphic gene, with > 100 polymorphisms identified (6).
A1AT deficiency is a relatively common condition that is characterized by decreased concentrations of plasma A1AT.
Thus, the measurement of the serum A1AT and the identification of the A1AT phenotype are clinically important.
A1AT deficiency is an autosomal codominant disorder with a prevalence of about 1:3000 in Caucasians [3].