5 HK

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5 HK

A highly conserved viral gene encoded by African swine fever virus (ASFV), which is an orthologue of mammalian Bcl-2, the protein product of which, p21, suppresses apoptotic cell death in various settings (e.g., that induced by growth factor deprivation in the mammalian lymphoid cell line) and cells (e.g., HeLa cells and the human myeloid leukemia cell line K562).
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References in periodicals archive ?
Alonso, "Functionality and cell anchorage dependence of the African swine fever virus gene A179L, a viral Bcl-2 homolog, in insect cells," Journal of Virology, vol.
The bcl-2-bax homologue (A179L) protein has 98.9%-100% aa identity in all isolates except Kenya 1950 and Benin 97/1, which are 94% identical compared with that of the Georgia 2007/1 isolate and other isolates.