AKAP13

(redirected from A-kinase anchoring protein)

AKAP13

A gene on chromosome 15q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of cAMP-dependent protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. Alternative splicing of AKAP13 results in at least 3 transcript variants that encode different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain with various functions. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, activating GTPase and resulting in signal transduction. The isoforms function as scaffolding proteins to co-ordinate a Rho-signalling pathway and function as PKA-anchoring proteins
References in periodicals archive ?
At telophase stage, PP1 (a Ser/Thr phosphatase) is targeted to lamin B by A-kinase anchoring protein (AKAP149) which is a membrane bound PP1 binding protein (Fig.2(c)).
They discuss structural characterization of EPAC by x-ray crystallography; sensory neuron cAMP signaling in chronic pain; monitoring real-time cyclic nucleotide dynamics in subcellular microdomains; identifying complexes of adenylyl with A-kinase anchoring proteins; assessing cyclic nucleotide binding domain allostery and dynamics by nuclear magnetic resonance spectroscopy; a protocol for expression and purification of cyclic nucleotide-free protein in E.