angiotensin II

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an·gi·o·ten·sin II

(an'jē-ō-ten'sin),
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.

angiotensin II

An octapeptide derived from angiotensin I after angiotensin-converting enzyme acts on angiotensin I, cleaving the C-terminal dipeptide. Angiotensin II is a potent vasoconstrictor (4- to 8-fold more potent that norepinephrine) and has a very short (1–2 minutes) T1⁄2 in the circulation; it induces arteriolar constriction and increases systolic and diastolic blood pressure. Angiotensin II acts directly on the adrenal cortex, increasing aldosterone secretion, facilitating norepinephrine release by direct action on the post-ganglionic sympathetic neurons. It acts on the brain, increasing water intake, vasopressin and ACTH secretion.

an·gi·o·ten·sin II

(an'jē-ō-ten'sin)
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.
References in periodicals archive ?
In most mammals, APO A-II is present in a monomeric form, whereas in humans, APO A-II also exists as a dimer of 2 identical chains, cross-linked by a single disulfide bond at cysteine-6 at the amino terminus of the protein (24, 25).
APO A-II is the second most abundant human HDL apolipoprotein and is synthesized predominantly in the liver (30).
Our data suggest that the overexpression of APO A-II in CSF from brain tumor patients might have resulted from protein leakage from the blood through a disrupted blood-brain barrier.
(6) suggested that APO A-II is a potentially specific marker for prostatic disease.
Of the 123 differentially expressed protein peak clusters, we identified a highly overexpressed m/z 17 000 peak cluster in CSF from brain tumor patients as APO A-II. The overexpression of APO A-II in CSF from brain tumor patients was correlated with an increased albumin concentration in CSF, which suggests a relationship with a disrupted blood-brain barrier.
Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer.
Isoproteins of human apolipoprotein A-II: isolation and characterization.
Isoforms of apolipoprotein A-II in human plasma and thoracic duct lymph.
Apolipoprotein A-II, genetic variation on chromosome 1q21-q24, and disease susceptibility.
Apolipoprotein A-II, HDL metabolism and atherosclerosis.
Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans.
Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice: relationship between the molecular type of apoA-II and mouse senile amyloidosis.