angiotensin II
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an·gi·o·ten·sin II
(an'jē-ō-ten'sin),A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.
angiotensin II
An octapeptide derived from angiotensin I after angiotensin-converting enzyme acts on angiotensin I, cleaving the C-terminal dipeptide. Angiotensin II is a potent vasoconstrictor (4- to 8-fold more potent that norepinephrine) and has a very short (1–2 minutes) T1⁄2 in the circulation; it induces arteriolar constriction and increases systolic and diastolic blood pressure. Angiotensin II acts directly on the adrenal cortex, increasing aldosterone secretion, facilitating norepinephrine release by direct action on the post-ganglionic sympathetic neurons. It acts on the brain, increasing water intake, vasopressin and ACTH secretion.an·gi·o·ten·sin II
(an'jē-ō-ten'sin)A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.
angiotensin II (anˈ·jē·ō·tenˑ·sin tōō),
n a powerful stimulant used to raise blood pressure by stimulating the release of aldosterone while concurrently causing vasoconstriction.