FABP4

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FABP4

A gene on chromosome 8q21 that encodes a lipid transport protein in adipocytes which plays a role in intracellular transport of long-chain fatty acids and retinoic acids, delivering them to their cognate receptors in the nucleus.
References in periodicals archive ?
Adipocyte fatty acid-binding protein (A-FABP, also referred to as FABP4, aP2) is highly expressed in adipocytes and macrophages and is extensively involved in inflammation and glucose and lipid metabolism [16].
Adipocyte-type FABP (A-FABP), also known as adipocyte protein 2 (aP2) and fatty acid binding protein 4 (FABP4), binds to long chain fatty acids and PPAR[gamma] agonists [69].
On the other hand, PVAT secretes adipocyte fatty acid binding protein (A-FABP) and adipose tissue-derived constricting factor (ADCF), which induce vasoconstriction and activate NADPH oxidase enzyme, increasing the release of reactive oxygen species (ROS) [17].
In crossbred gilts the expression of the adiponectin (ADIPOQ), adipocyte fatty acid-binding protein (A-FABP), and LEP genes was analysed in adipose and muscle tissues using qRT-PCR.
And A-FABP are markers of intramuscular adipocytes in which IMF is mainly stored (Hocquette et al., 2010).
H-FABP is the dominant FABP type in skeletal muscles, but A-FABP is also
(12,13) These include monitoring the levels of vitamin D, calcium (14), and magnesium intake, (15,16) as well as levels of C-reactive protein (CRP), (16,17,18,19) interleukin (TL)-6, (19) IL-10, (20) adiponectin, (19) adipocyte-fatty acid binding protein (A-FABP), (21) and plasminogen activator inhibitor (PAI)-1.
Especificidad por acidos grasos del alergeno Bio 113 LIGANDO Bio 113 A-FABP L-FABP ABA-1 A.
The functional importance of the ligand-induced conformational changes within the portal was demonstrated in the case of A-FABP. The binding of an activator ligand to A-FABP induces conformational changes within the portal region that leads to the formation of a nuclear localization signal (NLS) (Figure 7(b)) [43,44].
Many researchers have focused on the correlation between H-FABP, A-FABP and IMF content.
In addition, serum lipocalin-2 concentrations were positively associated with adipocyte-fatty acid binding protein (A-FABP), a novel serum marker for adiposity and metabolic syndrome (20).
Heart fatty acid binding protein gene (H-FABP) and adipocyte fatty acid binding protein gene (A-FABP) were supposed to influence intramuscular fat (IMF) deposition and backfat thickness.