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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).


Amyloid β peptide
References in periodicals archive ?
Prior to the stepdown date, principal on the series A-1 through A-4 and B notes will be applied sequentially and payable on each quarterly distribution date.
Effects of the vascular disrupting agent Combretastatin A-4 phosphate and radiation on the endothelial cytoskeleton and on endothelial monolayer permeability; Kanthou et al
The influence of different isoforms of VEGF-A on tumor vasculature maturation and response to the vascular disrupting agent, Combretastatin A-4 phosphate; Tozer et al