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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Amyloid β peptide
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
A-3 and A-4 parental lines are maintained by Pennington Seed/Seeds West, 37860 W.
Now comes another aspirant to the genre of Naval Aviation fiction--Commander Ward Carroll, a second-generation Naval Aviator whose Marine father flew A-4s in Vietnam.
WBCMT 2007-C33 Commercial Mortgage Trust, class A-4 certificates: 7.6% interest in the class A-4, in the amount of $71,692,364.
CWCI 2007-C3 Commercial Mortgage Trust, class A-4 certificate: 10.8% interest in the class A-4, in the amount of $71,468,173.