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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).


Amyloid β peptide
References in periodicals archive ?
The influence of different isoforms of VEGF-A on tumor vasculature maturation and response to the vascular disrupting agent, Combretastatin A-4 phosphate; Tozer et al
Tumor physiological response to anti-vascular agent Combretastatin A-4 phosphate assessed by magnetic resonance imaging; Zhao et al
The interaction of Combretastatin A-4 phosphate with pacliataxel and manumycin A in a mouse xenograft model of anaplastic thyroid cancer; Yeung et al