TNFSF13

(redirected from A proliferation-inducing ligand)

TNFSF13

A gene on chromosome 17p13.1 that encodes a cytokine of the tumour necrosis factor family, which binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. It is highly expressed in cancers of the colon, thyoid and lymphoid tissues; it may regulate tumour cell growth and be involved in macrophage-mediated immunity. It is popularly known as APRIL.
References in periodicals archive ?
The normal function of BCMA is to promote plasma cell survival by transduction of signals from two known ligands, BAFF (B-cell activating factor) and APRIL (a proliferation-inducing ligand).
Recent studies have shown that determination of serum concentrations of a proliferation-inducing ligand (APRIL) may be useful in differentiation of bacterial infections and nonbacterial inflammations.
A proliferation-inducing ligand is an indicator of the function of our immune system and its concentrations in body fluids are not routinely determined, but only for research purposes.
A proliferation-inducing ligand concentrations were significantly elevated in patients with confirmed bacterial infections compared to healthy individuals, similar to the research of Roderburg et al.
The plasma concentrations of a proliferation-inducing ligand are significantly higher in patients with confirmed bacterial infections than in healthy subjects, patients with B-cell malignancies and those with autoimmune inflammatory disorders.