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The normal function of BCMA is to promote plasma cell survival by transduction of signals from two known ligands, BAFF (B-cell activating factor) and APRIL (a proliferation-inducing ligand).
Recent studies have shown that determination of serum concentrations of a proliferation-inducing ligand (APRIL) may be useful in differentiation of bacterial infections and nonbacterial inflammations.
A proliferation-inducing ligand is an indicator of the function of our immune system and its concentrations in body fluids are not routinely determined, but only for research purposes.
A proliferation-inducing ligand concentrations were significantly elevated in patients with confirmed bacterial infections compared to healthy individuals, similar to the research of Roderburg et al.
The plasma concentrations of a proliferation-inducing ligand are significantly higher in patients with confirmed bacterial infections than in healthy subjects, patients with B-cell malignancies and those with autoimmune inflammatory disorders.
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