Aspergillus fumigatus

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Related to A fumigatus: Aspergillus fumigatus, aspergilli

As·per·gil·lus fu·mi·ga·tus

a fungal species that yields the antibiotics fumigacin and fumigatin; common cause of aspergillosis in humans and birds.

Aspergillus fumigatus

The fungal species that is the most common cause of human aspergillosis, which may enter via the lungs or less commonly skin, and which may invade blood vessels and disseminate to various organs. Aspergillus spp branch at 45º angle.
 
Vectors
Soil and organic debris, bird droppings.
 
Clinical findings
See table below.

Diagnosis
Complement fixation, immunodiffusion.
 
DiffDx
Pseudallescheria spp, fusariosis.

Pulmonary aspergillosis
• Allergic bronchopulmonary aspergillosis—Hypersensitivity reaction to the fungus and most common in asthmatics.
• Saprophytic aspergillosis (Aspergilloma)—Most common form; noninvasive; colonisation of pre-existing cavities.
• Chronic necrotising aspergillosis—Airway-invasive aspergillosis; semi-invasive aspergillosis; chronic cavitary pneumonic disease (often affects patients with preexisting chronic lung disease).
• Angioinvasive aspergillosis—Affects immunocompromised patients and is often fatal.

Aspergillus fumigatus

Microbiology The fungal species that is the most common cause of human aspergillosis, which may infect the lungs, invade blood vessels, or disseminate to various organs. See Aspergillosis.

As·per·gil·lus fu·mi·ga·tus

(as'pĕr-jil'ŭs fyūm'i-gā'tŭs)
Widely spread in the environment, a fungal species found in the soil or decaying vegetation; most common cause of aspergillosis in humans, particularly in the immunocompromised patient. Associated with pulmonary, bone, ocular, nasal, and deep organ disease; extremely angioinvasive.
References in periodicals archive ?
Fifty microliters of the heat-killed suspension of A fumigatus was added to each well of an ELISA plate.
One milliliter of heat-killed A fumigatus suspension ([10.sup.-3] units/mL) or 1 mL of PBS was mixed with 1 mL of IgY-rich extract (10 mg/mL) and incubated at 37[degrees]C for 1 hour.
The LD50 of the A fumigatus isolate was determined by the method described by Nowotny.
Moreover, lung homogenates were cultured on Sabouraud agar to confirm that death was due to A fumigatus. Note that all procedures involving the animals included in this study conformed to the ILAR Guide for the Care and Use of Laboratory Animals of the Institute of Laboratory Animal Research, Commission on Life Sciences, National Research Council.
Survival of mice treated with 5 mg protein/mouse of pre- or post-immunization yolk extract at different times with respect to challenge with 2LD50 of A fumigatus is given in Table 3.
(22,24) The increased incidence of A fumigatus infections in immunocompromised patients and the limited efficacy of anti-fungal drugs, led to the preparation of IgY anti-A fumigatus antibodies and testing their protective efficacy in mice.