ADAMTSac2

(redirected from A Disintegrin And Metalloproteinase with Thrombospondin Motifs)

ADAMTSac2

An ADAMTSs family enzyme encoded by ADAMTS2 on chromosome 5qter which removes N-terminal propeptides of collagen types 1, 2 and 5 before fibril assembly. ADAMTS2 mutations have been linked to Ehlers-Danlos syndrome type VIIC and to bovine dermatosparaxis. ADAMTS2 is expressed in monocytes and macrophages, and expression can be induced in osteosarcoma cells by TGF-beta.
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Recently, a new molecular substance has garnered much interest, namely, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS).
Abbreviation: ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs (original magnifications X200 [A, C, D, E, and F] and X400 [inset and B]).
Immunohistochemical Scoring of ADAMTS Proportion of Positive Intensity Total Score Remarks Cells Cytoplasmic Staining Pattern None (score, 0) No staining 0-1 Negative (score, 0) ~One-third (score, 1) Faint 2-3 Weak (score, 1) Nuclear Staining Pattern One-third to two- Moderate 4-5 Intermediate thirds (score, 2) (score, 2) > Two-thirds (score, 3) Strong 6 Strong (score, 3) Abbreviation: ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs.

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