9-cis-retinoic acid

9-cis-retinoic acid

AIDS A retinoid that may have some efficacy in topical management of KS Adverse effects Skin irritation, photosensitivity. See AIDSALRT 1057.
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Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.
Drew, "9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes," Journal of Neuroimmunology, vol.
Other treatments include local destruction (cryotherapy), topical alitretinoin (9-cis-retinoic acid), intralesional interferon or vinblastine, superficial radiotherapy, liposomal doxorubicin, daunorubicin, or paclitaxel.
The transcription of RXRs is activated by endogenous 9-cis-retinoic acid, which is a vitamin A derivative for regulation of growth and morphogenesis [18-21].
Combination treatment with 1alpha,25-dihydroxyvitamin D3 and 9-cis-retinoic acid directly inhibits human telomerase reverse transcriptase transcription in prostate cancer cells.
Efficacy and safety of oral alitretinoin (9-cis-retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial Ruzicka T, Lynde CW, Jemec GB et al.
All-trans retinoic acid (RA) and 9-cis-retinoic acid (9cRA) are activators of Retinoic Acid Receptors (RARs).
The retinoid X receptor (RXR) is a common heterodimeric partner for many receptors, including thyroid hormone receptor (TR), RAR, vitamin [D.sub.3] receptor (VDR), peroxisome proliferator-activated receptor (PPAR), liver X receptor (LXR), and FXR, in addition to functioning as a receptor for 9-cis-retinoic acid (9CRA) during formation of a homodimer.
Generally, TRs form heterodimers with the 9-cis-retinoic acid receptor and interact with comodulator complexes, thereby repressing or activating transcription.
The RXR-selective retinoids have a biological activity that is different from that of the endogenous retinoid 9-cis-retinoic acid (alitretinoin), the active substance in Panretin(R) gel and capsules.