Primaquine, like all 8-aminoquinoline
compounds, can result in severe haemolysis in individuals with G6PD deficiency, and screening for this enzyme defect is recommended before these medications are commenced.
The company said Tafenoquine is an 8-aminoquinoline
chemically derived from Primaquine, with activity against all types of malaria.
Pavez et al., "Influence of 8-aminoquinoline
on the corrosion behaviour of copper in 0.1 M NaCl," Electrochimica Acta, vol.
Primaquine, an 8-aminoquinoline
, is a prodrug requiring hydroxylation by the CYP2D6 enzyme within hepatocytes to transform into the active form .
Neves, "Synthesis, structure and physicochemical properties of zinc and copper complexes based on sulfonamides containing 8-aminoquinoline
ligands," Quimica Nova, vol.
Despite numerous studies carried out to evaluate antirelapse potential of existing and new antimalarials such as Tafenoquine, and its combinations [6-8], Primaquine (PQ), an 8-aminoquinoline
, remains at present the only agent available worldwide to prevent relapses .
Core-shell mesoporous silica nanospheres encapsulated with Rhodamine 101 into the solid core and 8-aminoquinoline
derivatives (AQ) into the mesoporous shell were used as [Zn.sup.2+] ratiometric fluorescent sensor .
CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline
, anti-malarial drug primaquine.
The endoperoxide OZ439, currently in Phase II clinical trials, and a new 8-aminoquinoline
, NPC-1161B, also demonstrated transmission-blocking potential.
A new 8-aminoquinoline
tafenoquine is on clinical trial as a potential replacement for primaquine to treat Plasmodium vivax malaria (Shanks 2001) and holds promise as a prophylactic against Plasmodium falciparum (Shanks 2001).