HSPA5

(redirected from 78 kDa glucose-regulated protein)

HSPA5

A gene on chromosome 9q33.3 that encodes a member of the heat shock 70 (HSP70) family which is localised in the lumen of the endoplasmic reticulum, where it is involved in protein folding and assembly. 

Molecular pathology
HSPA5 is an autoantigen implicated in the pathogenesis of rheumatoid arthritis.
References in periodicals archive ?
Binding immunoglobulin protein (BiP), also known as 78 kDa glucose-regulated protein (GRP78), is a lumen-resident molecular chaperone which is markedly up-regulated under ER-stress, dissociating from the three sensor proteins to activate each UPR pathway when unfolded and misfolded proteins are accumulated in the ER.