MMP2

(redirected from 72 kDa gelatinase)

MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.
References in periodicals archive ?
However, the effects of both diabetes and CMC 2.5 treatment on plasma MMP-2 were not statistically significant, although the pattern of change for this 72 kDa gelatinase paralleled the changes seen for the other MMPs (Figure 7).