CCL21

(redirected from 6Ckine)

CCL21

A gene on chromosome 9p13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL21 binds CCR7, inhibits haemopoiesis and is chemotactic for thymocytes and activated T cells—but not B cells, macrophages or neutrophils; it may also play a role in homing lymphocytes to secondary lymphoid tissue.
Mentioned in ?
References in periodicals archive ?
Capucilli, MD (Fellow-in-Training), Children's Hospital of Philadelphia, for his abstract entitled "A Comparison of Comorbid Diagnoses in Children with and without Eosinophilic Esophagitis in a Large Primary Care Population," and Ichiro Nomura, MD (Member), National Research Institute for Child Health and Development, for his abstract entitled "Elevated Serum TSLP, IL-33, 6Ckine and MCP-3 Levels in School Children or Older Patients with Eosinophilic Gastroenteritis."
Group I- Group II- preterm labor false preterm labor n = 62 n = 47 Chemokines concentration (pg/mL) Median (min-max) 6Ckine 11539 (2713-77761) 12543 (3226-39407) Axl 1306 (529.5-7509) 1389 (601.4-3074) BTC 8924 (5577-32195) 8246 (5383-18495) CCL28 13504 (7193-41772) 13959 (7923-78508) CTACK/CCL27 3831 (1028-93251) 4138 (1006-25364) CXCL16 2849 (1789-7924) 2844 (1260-13175) ENA-78/CXCL5 2894 (380.8-16116) 2728 (799.4-19843) Eotaxin-3 4545 (2229-18529) 4269 (1507-23502) GCP-2 709.7 (132.1-2507) 743.8 (190-1841) GRO [alpha].
On the other hand, in the same amniotic fluid of fetuses with Down syndrome, as compared with control, we observed a significant increase in the concentration of 4 chemokines: 6Ckine, IP-10, MPIF-1, and CXCL7 (Table 3).
McEvoy, "The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3[beta] are potent chemoattractants for in vitro- and in vivo-derived dendritic cells," Journal of Immunology, vol.