reductase

(redirected from 5alpha-reductase)
Also found in: Dictionary, Thesaurus, Wikipedia.

reductase

 [re-duk´tās]
an enzyme that catalyzes a chemical reduction.
5α-reductase an enzyme that catalyzes the irreversible reduction of testosterone to dihydrotestosterone.

re·duc·tase

(rē-dŭk'tās),
An enzyme that catalyzes a reduction; because all enzymes catalyze reactions in either direction, any reductase can, under the proper conditions, behave as an oxidase and vice versa, hence the term oxidoreductase. For individual reductases, see the specific names.
Synonym(s): reducing enzyme

reductase

/re·duc·tase/ (-tās) a term used in the names of some of the oxidoreductases, usually specifically those catalyzing reactions important solely for reduction of a metabolite.
5α-reductase  an enzyme that catalyzes the irreversible reduction of testosterone to dihydrotestosterone; enzyme deficiency leads to a form of male pseudohermaphroditism.

reductase

(rĭ-dŭk′tās′, -tāz′)
n.
Any of various enzymes that catalyze the reduction of an organic compound.

reductase

A generic term for any enzyme that catalyses a chemical reduction reaction.

re·duc·tase

(rĕ-dŭk'tās)
An enzyme that catalyzes a reduction; because all enzymes catalyze reactions in either direction, any reductase can, under the proper conditions, behave as an oxidase and vice versa; hence the term oxidoreductase.

reductase

an ENZYME that catalyses the REDUCTION of a compound.

reductase

an enzyme that catalyzes a chemical reduction.

5α-reductase
an enzyme that catalyzes the irreversible reduction of testosterone to dihydrotestosterone.
References in periodicals archive ?
A new look at the 5alpha-reductase inhibitor finasteride.
Inhibition of type 1 and type 2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon.
Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract.
Diagnosis of 5alpha-reductase 2 deficiency: a local experience.
New mutations, hotspots, and founder effects in Brazilian patients with steroid 5alpha-reductase deficiency type 2.
Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor.
Alpha-blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5alpha-reductase inhibitor dutasteride.
5alpha-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia.
A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.
Drug Insight: 5alpha-reductase inhibitors for the treatment of benign prostatic hyperplasia.
Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor.