Regarding the treatment choices, the most common therapeutic choices were monotherapy with an a-blocker (48.6%) or 5a-reductase inhibitors
(30.6%) or their combination (18.9%).
Primary prevention of PCa has focused on chemoprevention, vitamin supplements (selenium, Vitamin E, and Vitamin C), and 5a-reductase inhibitors
(finasteride and dutasteride).
The Risks and Benefits of 5a-Reductase Inhibitors
for Prostate-Cancer Prevention.
They compared 2312 Icelandic men who underwent medical or surgical management for BPH (including treatment with 5a-reductase inhibitors
, which are known to lower the PSA concentration) vs 33 779 presumed-healthy Icelandic men.
A second category of medicines includes what are termed the 5a-reductase inhibitors
, including Proscar and Avodart.
Use of 5a-reductase inhibitors
for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline.