5alpha-reductase inhibitors

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5α-reductase inhibitors

Drugs that inhibit the action of 5α-reductase, resulting in lower levels of prostatic dihydrotestosterone, the primary androgen in the prostate.
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Primary prevention of PCa has focused on chemoprevention, vitamin supplements (selenium, Vitamin E, and Vitamin C), and 5a-reductase inhibitors (finasteride and dutasteride).
Current Progress and Controversies in Prostate Cancer Management
The Risks and Benefits of 5a-Reductase Inhibitors for Prostate-Cancer Prevention.
The effect of dutasteride on the detection of prostate cancer: A set of meta-analyses
They compared 2312 Icelandic men who underwent medical or surgical management for BPH (including treatment with 5a-reductase inhibitors, which are known to lower the PSA concentration) vs 33 779 presumed-healthy Icelandic men.
Germline sequence variants and prostate-specific antigen interpretation
A second category of medicines includes what are termed the 5a-reductase inhibitors, including Proscar and Avodart.
Prostate: new light on laser therapy: for the millions of males living with benign prostatic hyperplasia (BPH), a new laser treatment is proving a promising alternative to more invasive surgery
Use of 5a-reductase inhibitors for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline.
Can chemoprevention reduce the risk of prostate cancer?
3 5a-Reductase Inhibitors - The Finasteride Story (J.
Research and Markets: The Art of Process Chemistry - Providing Must-Have Knowledge for the Pharmaceutical Industry
Because of the ability of 5a-reductase inhibitors to inhibit the conversion of testosterone to DHT, finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant woman who receives finasteride.
Large-scale trial establishes benefits of long-term management of prostate disease (PART III OF V)
The changes described above are expected pharmacological effects of drugs belonging to the class of 5a-reductase inhibitors and are similar to those reported in male infants with a genetic deficiency of 5a-reductase.
Large-scale trial establishes benefits of long-term management of prostate disease (PART V OF V)
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