5-oxoproline

5-ox·o·pro·line (Glp),

(ok'kō-prō'lēn),
A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and γ-glutamylated peptides; it is also produced by the action of γ-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism.
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Moreover, the relative contents of 6PG, 5-oxoproline, and N-acetyllysine increased, while that of phosphoribosyl pyrophosphate (PRPP) decreased during beef aging (adjusted p<0.05, FDR<0.10; Supplementary Table S1).
Additionally, the levels of 5-oxoproline, methionine and arachidonic acid were also significantly elevated in female rats within exhaustive exercise, suggesting that exhaustive exercise induced diverse responses to oxidative stress in female rats.
Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle.
The urine gas chromatography/mass spectrometry showed massive excretion of 5-oxoproline. Table 1 shows laboratory findings of the patient on Day of Life #6.
Michopoulos et al., "HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium," Journal of Pharmaceutical and Biomedical Analysis, vol.
Glutathione metabolites, including multiple gamma-glutamyl amino acids, cysteine-glutathione, and 5-oxoproline, were lower in small dogs.
Here, we identified the metabolites (5-oxoproline, L-ornithine), transcripts(GSTM4), proteins(GSTA4), and potential targets (GSR, GSTP1, GSTM1/2), which were mainly related to glutathione metabolism.
Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen.
Earlier studies of the total urinary content of amino acids released by acid hydrolysis (24) indicated an upper limit for peptide excretion of 1 g/day, a large proportion of which might be accounted for by abundant amino acid derivatives such as hippuric acid, 5-oxoproline, and phenylacetylglutamine (25-27).
A pyroglutamic acid (5-oxoproline) level was also markedly elevated (1843 [micro]g/mg of creatinine, 18 times the normal level).
Urinary excretion of 5-oxoproline (pyroglutamic aciduria) as an index of glycine insufficiency in normal man.
However, two adult subjects with metabolic acidosis, one with an increased anion gap, have been described in whom 5-oxoproline (pyroglutamic acid) was responsible for the acidosis (1, 2).

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