5-methyltetrahydrofolate


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5-methyltetrahydrofolate

/5-meth·yl·tet·ra·hy·dro·fo·late/ (-tet″rah-hi″dro-fo´lāt) a derivative of folic acid that is the principal form of folic acid during transport and storage in the body and that also acts as a source of methyl groups for the regeneration of methionine.
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sup][60] MTHFR is a crucial enzyme of one-carbon metabolism as it catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cofactor that directs the folate pool toward the remethylation of homocysteine to methionine.
Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia.
Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
Methionine synthase (MS) is a key component of the methionine cycle in one-carbon metabolism and it catalyzes the conversion of homocysteine (HCY) to the essential amino acid methionine, utilizing a methyl group derived from 5-methyltetrahydrofolate.
Future studies should examine whether supplementation with 5-methyltetrahydrofolate, or co-supplementation with methyl donors such as choline or betaine, can provide an additional benefit in lowering bAs.
There are various causes of hHcy but mainly it is due to enzyme deficiencies cystathionine p synthase, methionine synthase, 5-methyltetrahydrofolate reductase or vitamin deficiencies-folate, vitamin B6 or B12.
Compartmentation of folate metabolism in rat pancreas: nitrous oxide inactivation of methionine synthase leads to accumulation of 5-methyltetrahydrofolate in cytosol.
45 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism is responsible for the circulation form of folate and 5-methyltetrahydrofolate which is involved in DNA synthesis and methylation.
Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate.
As expected, the measured plasma levels of folate and 5-methyltetrahydrofolate, vitamin B12, and pyridoxal-5'phosphate (PLP) increased significantly, while MMA levels decreased.
In an alternative set of reactions, 5,10-MTHF also can be converted to 5-methyltetrahydrofolate (5-MTHF) in a reaction catalyzed by the enzyme methylenetetrahydrofolate reductase (MTHFR).

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