The hormone and its metabolites (6-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine [AFMK], N-acetyl-serotonin, and 5-methoxytryptamine
) reduce UVB-induced oxidative cell damage in human keratinocytes and melanocytes, and also act as radioprotectors.
Melatonin is converted to 5-methoxytryptamine by deacetylation.
Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms.
Going further with his strongly spiritual view of the healing process, Lissoni found that the different neuro-hormones produced by the pineal gland could help oncologic patients to restore the natural immune-biological resistance against tumor growth, through the regularization of the rhythm of production of four main pineal indoles produced and released at very specific time-points: namely, i) 5-methoxytryptophol (5-MLT) at midday, ii) 5-methoxytryptamine (5-MT) at sunset, iii) melatonin (MLT) during the night, and iv) 5-methoxy-3-indole acetic acid (5-MIAA) on the early morning.
Tryptamine, N,N-dimethyltryptamine, N,N-dimethyl-5-hydroxytryptamine and 5-methoxytryptamine in human blood and urine.
Scientists detected melatonin metabolite 5-methoxytryptamine and the melatonin analogue N, N-dimethyl-5-methoxytryptamine in those living organisms.
Melatonin and 5-methoxytryptamine in non-metazoans.
(29) Yu et al (27) found that CYP2D6 may be an additional pathway to regenerate serotonin through 0-demethylation from 5-methoxytryptamine
, but it is unclear what proportion of the physiologic pool of serotonin in synaptic nerve terminals is generated through the CYP2D6 pathway.
Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin and 5-methoxytryptamine
. Endocrinology 100: 675-678.
Aghajanian, "Melatonin: deacetylation to 5-methoxytryptamine
by liver but not brain aryl acylamidase," Journal of Neurochemistry, vol.
Biochemotherapy with immunomodulating pineal hormones other than melatonin: 5-methoxytryptamine
as a new oncostatic pineal agent.
Tryptamines most frequently used among consumers are a-methyltryptamine (AMT) and three kinds of 5-methoxytryptamines
: 5-MeO-DMT, 5-MeO-DiPT (Foxy Methoxy) and N,N-dyalil-5-methoxytriptamine or 5-MeO-DALT.