ALOX5

(redirected from 5-lipoxygenase)

ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.

Mentioned in ?

5-LO

References in periodicals archive ?

MN-001 (tipelukast) is a novel, orally bioavailable small molecule compound thought to exert its effects through several mechanisms to produce its anti-inflammatory and anti-fibrotic activity in preclinical models, including leukotriene (LT) receptor antagonism, inhibition of phosphodiesterases (PDE) (mainly 3 and 4), and inhibition of 5-lipoxygenase (5-LO).

MediciNova Announces MN-001 Research Collaboration with the National Cerebral and Cardiovascular Disease Research Center in Japan

Melatonin inhibits the transcription of the 5-lipoxygenase gene, a gene involved in the onset of inflammation; therefore, we can say that darkness represses the expression of the 5-lipoxygenase gene.

EPIGENETICS AND CONTROL OF GENE EXPRESSION

Additionally, CMV infection is shown to increase 5-lipoxygenase (5-LO) and leukotriene B4 in vascular smooth muscle cells.

A RARE PRESENTATION OF CYTOMEGALOVIRUS INFECTION IN A RENAL TRANSPLANT RECIPIENT: PNEUMONIA ACCOMPANIED BY AORTIC ANEURYSM INFECTION/DISSECTION/BOBREK NAKLI ALICISINDA SITOMEGALOVIRUS ENFEKSIYONUN NADIR BIR PREZENTEASYONU: PNOMONI VE ESLIK EDEN AORT ANEVRIZMA ENFEKSIYONU/DISEKSIYONU

Currently, the anti-inflammatory non-steroid drugs present on the pharmaceutical market, reduces the conversion of arachidonic acid into prostaglandins by inhibiting the cyclooxygenase enzyme [18-23], however, does not inhibit 5-lipoxygenase enzyme.

Molecular Docking Studies of Natural Phenolic Compound and Derivates with Phospholipase A2

When the animals were 12 months old, the equivalent of age 60 in humans, they were treated with zileuton, a drug that inhibits leukotriene formation by blocking the 5-lipoxygenase enzyme.

Researchers Reverse Cognitive Impairments in Mice with Dementia

The reason being attributed principally to inhibition of biosynthesis of cytoprotective prostaglandins such as prostaglandin E and prostacyclin by inhibition of cyclooxygenase pathway of arachidonic acid metabolism, resulting in overproduction of leukotrienes and other products of 5-lipoxygenase pathway.

Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats

Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages.

Plant Compounds that Reduce Joint Cartilage Loss

MN-001 is a novel and orally bioavailable small molecule compound, which is believed to exercise its effects through various mechanisms to produce its anti-inflammatory and anti-fibrotic activity in preclinical models, including leukotriene receptor antagonism, inhibition of phosphodiesterases (PDE) (mainly three and four), and inhibition of 5-lipoxygenase.

MediciNova's liver disease drug meets primary endpoint in phase 2 clinical trial

Are Tolfenamic acid and tenidap dual inhibitors of 5-lipoxygenase and cyclo-oxygenase.

Therapeutic Efficacy of Tolfenamic Acid 8% in Respiratory Diseases of Bovines

COX pathways consist of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), while 5-lipoxygenase (5-LOX), 12-lipoxygenase (12-LOX), and 15-lipoxygenase (15-LOX) are the examples of the LOX pathway.

A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity

To this, 50 [micro]l of the 5-lipoxygenase enzyme (400 units/ml cold 2 M borate buffer, pH 6.9) was added and incubated at room temperature for 5 min.

Phytochemical Screening, Antioxidant, Anti-inflammatory, and Glucose Utilization Activities of Three South African Plants Used Traditionally to Treat Diseases