ALOX5

(redirected from 5-lipoxygenase)

ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
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Nigella sativa, an herb exclusively used in traditional medicine, is reported to inhibit both cyclooxygenase (COX) and 5-lipoxygenase pathways of arachidonic acid metabolism.
Overexpression of 5-Lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.
Boswelia serrata has been found to specifically inhibit the powerful pro-inflammatory enzyme, 5-lipoxygenase.
Hence it was shown that a number of pivotal enzymes in inflammation like 5-lipoxygenase (5-LO), cyclooxygenase-1 (COX-1), human leuokocyte elastase (HLE), cathepsin G (catG) and the microsomal prostaglandin E synthase-1 (mPGES-1) as well as the nuclear factor-kappaB (NF-[kappa]B) and several cytokines like TNF[alpha], IL-1[beta] and IL-6 are inhibited by BAs with [IC.
The effect of 5-lipoxygenase inhibition on blood-brain barrier permeability in experimental brain tumors.
The root of Zingiber officinale (ginger) has previously demonstrated anti-inflammatory activity through inhibition of COX-2, NF-[kappa]B and 5-lipoxygenase (5-LOX).
According to the company, MN-001 (tipelukast) is a novel, orally bioavailable small molecule compound thought to exert its effects through several mechanisms to produce its anti-inflammatory and anti-fibrotic activity in preclinical models, including leukotriene (LT) receptor antagonism, inhibition of phosphodiesterases (PDE) and inhibition of 5-lipoxygenase (5-LO).
found that extracts of Aceriphyllum rossii (native to Korea and China) and its active constituents, quercetin and kaempferol, blocked secretion of beta-hexosaminidase and histamine; lowered the production and mRNA expression of interleukin-4 and TNF-alpha; and reduced prostaglandin E2 and leukotriene B4 synthesis as well as the expression of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (J.
In humans, initial oxygenation of arachidonic acid via 15-lipoxygenase type I and then by 5-lipoxygenase is one route of lipoxin biosynthesis that has been observed in mucosal tissues, such as the respiratory tract, gastrointestinal tract and oral cavity, and that results from the interactions between epithelial cells and leukocytes.
Different treatment modalities like cryotherapy, scarification, topical and systemic steroids, antimalarials, chlorambucil, ciclosporin, dapsone, etretinate, fumaric acid esters, isotretinoin, niacinamide, pentoxifylline, photo(chemo)therapy, potassium iodide, zileuton (a 5-lipoxygenase inhibitor), vitamin E have been tried with variable responses.
Among the topics are developing palladium-catalyzed arylations of carbonyl-activated carbon-hydrogen bonds, process development and scale-up of a novel antibiotic, copper-catalyzed carbon-nitrogen coupling on a large scale, transition metal-catalyzed coupling reactions in the synthesis of taranabant, developing Migita couplings for the manufacture of a 5-lipoxygenase inhibitor, and applying the hydrophobic effect to transition metal-catalyzed couplings in water at room temperature.
18) One way that the body rids itself of excess arachidonic acid is by provoking a dangerous metabolizing pathway through 5-lipoxygenase (5-LOX).

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