5-hydroxytryptophan

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5-hydroxytryptophan

(hī-drok″sē-trip′tŏ-fan″),

5HTP

An amine that is a precursor of serotonin. It is marketed as a dietary supplement for depression, insomnia, and weight loss.
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Moreover, 5-hydroxy-tryptophan has frequently been associated with L-tryptophan.(133) L-tryptophan was removed from the market after a contaminated batch may have caused eosinophilia-myalgia syndrome (EMS), a rare blood disorder.(134) In more than 1,500 instances L-tryptophan use (as a sleep aid, appetite suppressant, or menstrual cramp reliever) was linked to EMS.(135) In addition, as many as thirty-eight deaths were related to EMS and L-tryptophan.(136) The L-tryptophan scandal revealed, via victim testimony before Congress, that consumers assumed that the FDA monitored this product.(137)
OBJECTIVE: In obese patients, brain serotonergic stimulation via orally administered 5-hydroxy-tryptophan (5-HTP), the precursor of serotonin, causes decreased carbohydrate intake and weight loss.