5-fluorocytosine


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5-fluorocytosine

References in periodicals archive ?
We found statistically significant correlations between increased resistance to 5-fluorocytosine and higher activity of acid phosphatase; increased resistance to ketoconazole and higher activity of beta-glucuronidase; increased resistance to miconazole and higher activity of beta-glucosidase; increased resistance to itraconazole and higher activity of N-acetyl-beta-D-glucosidase, as well as increased susceptibility to itraconazole and higher enzymatic activity of cystine arylamidase and naphthyl phosphohydrolase.
For comparison, the control 5-fluorocytosine was routinely used as a reference in this test and gave an MIC of 0.
It also catalyses the deamination of 5-fluorocytosine to (5FC) to 5-fluorouracil (5FU).
It is currently being investigated in preclinical studies as a novel anticancer agent with the potential to express anti-tumor effects when administered in combination with the antifungal agent 5-fluorocytosine (5-FC).
In vitro sensitivity of Aspergillus to terbinafine: comparative study on amphotericin B, 5-fluorocytosine and ketoconazole [in French].
The fluoropyrimidine 5-fluorocytosine (5-FC) is an FDA-approved drug in this class although it has a limited spectrum of activity and significant potential for toxic effects (36-37).
Feline phaeohyphomycosis: treatment with ketaconazole and 5-fluorocytosine.
This excerpt from an existing 5-fluorocytosine assay procedure shows the XML source code for a specimen requirements section.
A combination of amphotericin B, 5-fluorocytosine, and itraconazole was associated with improved survival, but only six patients in the series received this combination.
56-57] For example, cells may be transfected with cytosine deaminase; treatment with the nontoxic compound 5-fluorocytosine then results in the local production of the toxic metabolite 5-fluorouracil.
In one, the enzyme cytosine deaminase converts the nontoxic compound 5-fluorocytosine into the potent anticancer drug 5-fluorouracil.