5-flucytosine

5-flucytosine

a fluorinated pyrimidine used as a systemic antifungal agent in the treatment of severe candidal and cryptococcal infections.
References in periodicals archive ?
Azathioprine was suspended, prednisone was tapered off to 10 mg per day, and amphotericin B and 5-flucytosine were introduced for six weeks.
The susceptibility profile showed 89% sensitivity to fluconazole, 98% to voriconazole, 87% to caspofungin, 94% to micafungin, 77% to amphotericin B, and 81% to 5-flucytosine.
Antifungal MIC, Epidemiologic Categorical drug Hg/mL cutoff value, classification, [micro]g/mL WT or non-WT (a) Amphotericin B 1 1 WT 5-Flucytosine 4 16 WT Voriconazole 0.
Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association.
Subsequently, she was diagnosed with cryptococcal meningitis, and treatment with amphotericin B and 5-flucytosine was initiated.
The currently available antifungal agents, amphotericin B, natamycin, fluconazole, ketoconazole, 5-flucytosine, itraconazole and voriconazole have limitations of poor penetration into the eye, limited spectrum of activity and surface toxicity, (4,5) Surgical intervention in the form of therapeutic keratoplasty is required more often in fungal keratitis compared with bacterial keratitis indicating a poor response to treatment with antifungal agents.
Overall the isolates were susceptible to both amphotericin B (MIC90 1g/ml) and to 5-flucytosine (MIC90 0.
Antifungal susceptibility testing was performed against amphotericin B, 5-flucytosine, fluconazole, itraconazole, and voriconazole by broth microdilution using API system (ATB FUNGUS 3, bioMerieux, France), during 2008.
2]O) showed evidence of yeast; she was given liposomal amphotericin B and 5-flucytosine and was transferred to a referral hospital, where she received a lumbar puncture to drain CSF and endotracheal intubation for mechanical ventilation in the intensive care unit.
Etkenin kandida oldugu vakalarda intravenoz amfoterisin B ile birlikte 5-flucytosine veya flukonazol onerilmekte (13), ek olarak yapilan calismalarda intraventrikuler konvansiyonel amfoterisin B (0.
In the absence of 5-flucytosine, the writers believe that southern African patients should be treated with the higher dose of amphotericin B 1 mg/kg/dose.