(redirected from 5-deoxyadenosylcobalamin)


An active coenzyme form of vitamin B12; required in the conversion of methylmalonyl-CoA to succinyl-CoA. A deficiency of 5'-deoxyadenosylcobalamin produces methylmalonic acidemia.
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2), which requires 5-deoxyadenosylcobalamin (AdoCbl) as a cofactor.
The biologically active coenzyme forms of vitamin B12 that play a role in human metabolism are methylcobalamin and 5-deoxyadenosylcobalamin (commonly known as adenosylcobalamin).
Its two metabolically active forms, methyl-cobalamin and 5-deoxyadenosylcobalamin, are coenzymes in the reactions catalyzed, respectively, by methionine synthase and methylmalonyl-CoA mutase.