5-alpha-reductase inhibitors

5-α-re·duc·tase in·hib·i·tors

(rĕ-dŭk'tās in-hib'i-tŏrz)
Drugs that inhibit the action of 5α-reductase, resulting in lower levels of prostatic dihydrotestosterone, produced by the enzyme from testosterone as the primary androgen in the prostate.
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References in periodicals archive ?
A team led by Edinburgh University and University College London studied about 55,000 men in the UK, who had been prescribed 5-alpha-reductase inhibitors over an 11-year period.
Diabetes link to prostate medicines
5-alpha-reductase inhibitors (5-ARIs) are a totally different kind of drug, which shrink the glandular tissue of the prostate, reducing its bulk to eventually reduce constriction by the prostate as well.
How's your walnut, mate? Why men don't like to talk about their enlarged prostate
1).[sup.4] The mainstay of medical treatments includes alpha-blockers, 5-alpha-reductase inhibitors (5-ARIs), or a combination of the two.
Update on medical therapy for male LUTS
First-line therapies indude alpha-1 adrenergic receptor antagonists (alpha-blockers) and 5-alpha-reductase inhibitors (5-AR1s).
What matters: With tamsulosin, don't forget the dip
Exclusion criteria also included: consumption of food rich in soy isoflavonoids, dietary supplements of any kind, medication with possible effects on prostate health such as antibiotics, anti-inflammatory drugs, alpha-1 -adrenoreceptor antagonist and 5-alpha-reductase inhibitors.
Use of selenium-silymarin mix reduces lower urinary tract symptoms and prostate specific antigen in men
Cancer chemopreventive approaches may include 5-alpha-reductase inhibitors, histone deacetylase inhibitors, antioxidans, non-steroidal anti-inflammatory drugs, cholesterol-lowering statins, vitamin D analogues.
Hereditary/familial versus sporadic prostate cancer: few indisputable genetic differences and many similar clinicopathological features
FDA-approved conventional medications used to treat BPH are of two categories, alpha-antagonists and 5-alpha-reductase inhibitors.
Benign prostatic hyperplasia and the conventional and alternative and complementary management of associated lower urinary tract symptoms
Adverse side effects of 5-alpha-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.
The shrinking case for saw palmetto: findings of this study should make physicians and patients alike reconsider the popularity of this herbal remedy for BPH symptoms
Patients were excluded if they had used 5-alpha-reductase inhibitors, if they had undergone prior prostate surgery, had a prior diagnosis of prostate cancer, had used androgen ablative therapies, had evidence of prostatitis, or if they were allergic to fluoroquinolones.
Antibiotics appear to have no effect on PSA levels
Drugs known as 5-alpha-reductase inhibitors like finasteride (Proscar) are widely used to treat benign prostatic hyperplasia (enlarged prostate).
Medications for enlarged prostate do not increase hip fracture risk
Medications called 5-alpha-reductase inhibitors (Proscar, for example) help shrink the prostate.
Prostate problem
Previous treatment with 5-alpha-reductase inhibitors was not allowed and alpha-blockers were discontinued at least 14 days prior to study.
THRESHOLD GETS POSITIVE RESULTS FROM TH-070 PHASE 2 BPH TRIAL

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