One such critical enzyme is 5-alpha-reductase
(5[alpha]-R): When its effects go awry, the consequences can be dramatic--altering the body via sex hormones and nervous system function through its neurosteroids.
inhibitors (5-ARIs) are a totally different kind of drug, which shrink the glandular tissue of the prostate, reducing its bulk to eventually reduce constriction by the prostate as well.
12 It is believed that in hirsute women, higher levels of 5-alpha-reductase
can be found in skin, so it gave us the clue to use topical finasteride in order to lower this enzyme's activity in skin and as a consequence reduce unwanted hair in the affected area, especially on the face and chin.
Dihydrotestosterone (DHT) is a male hormone produced from testosterone by an enzyme called 5-alpha-reductase
6%) have sex reassignment, 15 from male to female (mainly cases of congenital adrenal hyperplasia, mixed gonadal dysgenesis, and 46,XX ovotesticular DSD) and 12 from female to male (mainly 5-alpha-reductase
type 2 deficiency).
4] The mainstay of medical treatments includes alpha-blockers, 5-alpha-reductase
inhibitors (5-ARIs), or a combination of the two.
First-line therapies indude alpha-1 adrenergic receptor antagonists (alpha-blockers) and 5-alpha-reductase
The genital tubercle is sensitive to dihydrotestosterone and rich in 5-alpha-reductase
, so that the amount of fetal testosterone present after the second month is a major determinant of phallus size at birth.
Exclusion criteria also included: consumption of food rich in soy isoflavonoids, dietary supplements of any kind, medication with possible effects on prostate health such as antibiotics, anti-inflammatory drugs, alpha-1 -adrenoreceptor antagonist and 5-alpha-reductase
When testosterone interacts with the enzyme 5-alpha-reductase
, DHT is created in the scalp.
A new mutation of 5-alpha-reductase
type 2 (A62E) in a large Egyptian kindred.
The significant adverse effects of alpha-blockers and 5-alpha-reductase
inhibitors, which are typically prescribed for LUTS--including decreased libido and dizziness--may help account for their interest in this alternative treatmentP.