Finasteride (Proscar[R], Propecia[R]) and dutasteride (Avodart[R]) are in a class of medications called 5-alpha reductase inhibitors
because they block the effects of the enzyme and prevent the conversion of testosterone to DHT, but they don't reduce testosterone levels.
Adverse Effects and Safety of 5-Alpha Reductase Inhibitors
(Finasteride, Dutasteride): A Systematic Review.
Although medical treatment of BPH with alpha blockers and 5-alpha reductase inhibitors
may ameliorate the urinary symptoms, surgical intervention may be inevitable in some patients.
8] Two studies have shown that 5-alpha reductase inhibitors
(5ARIs) reduce the risk of prostate cancer.
Reasons for the current stagnation of progress include failure of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) to show preventive activity of selenium and vitamin E; the failure of a high-risk phase III study to show preventive activity of selenized yeast; the refusal of the Food and Drug Administration to approve finasteride for prostate cancer prevention; and uncertainty regarding the long-term effects of treatment with 5-alpha reductase inhibitors
, according to Dr.
20) The current approach for medical management of LUTS associated with BPH depends on the usage of alpha-1 receptor blockers, such as alfuzosin, doxazosin, silodosin, tamsulosin and terazosin or suppression of the hormonal growth of the prostate by the 5-alpha reductase inhibitors
finasteride and dutasteride.
A review of several published reports attribute the higher Gleason scores observed in the groups taking the 5-alpha reductase inhibitors
(Avodart[R] or Proscar[R]) to the fact that it was easier to find high-grade cancers in the shrunken glands of men taking these drugs compared to the much larger glands of men in the placebo group.
The two main classes of BPH drugs: alpha blockers like Flomax and UroXatral, which relax the muscles of the bladder neck and prostate, and 5-alpha reductase inhibitors
like Proscar and Avodart, which lower levels of hormones produced by the prostate.
For men with significant enlargement, drugs called 5-alpha reductase inhibitors
(5-ARIs) are available to shrink the prostate.
These include alpha blockers like tamsulosin (Flomax), which provide quick symptom relief, and 5-alpha reductase inhibitors
like dutasteride (Avodart), which help shrink the prostate over time.
Medications known as 5-alpha reductase inhibitors
(5-ARIs) do not increase the likelihood of suicide, but they are associated with a greater risk of depression and self-harm, a recent study suggests.
1093/ annonc/mdq695), suggest that men with early baldness may benefit from routine prostate cancer screening or preventive measures that could include the systematic use of 5-alpha reductase inhibitors
, the researchers wrote.