5-alpha reductase


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5-alpha reductase

(al'fa re-duk'tās),
Intracellular enzyme that converts testosterone to 5-alpha dihydrotestosterone (DHT). Two distinct isoforms are known in humans and laboratory animals.

5-alpha reductase

An enzyme that converts testosterone to dihydrotestosterone.
See also: reductase
References in periodicals archive ?
There are much safer ways to create mechanisms of action for 5-alpha reductase inhibition and for aromatase inhibition at the same time.
Reasons for the current stagnation of progress include failure of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) to show preventive activity of selenium and vitamin E; the failure of a high-risk phase III study to show preventive activity of selenized yeast; the refusal of the Food and Drug Administration to approve finasteride for prostate cancer prevention; and uncertainty regarding the long-term effects of treatment with 5-alpha reductase inhibitors, according to Dr.
Isoflavones have variable effects on growth factor inhibition [6], antioxidant properties [7, 8], cell adhesion [9], 5-alpha reductase activity [10, 11], and angiogenesis [12].
Another virtue to using 5-alpha reductase inhibitors (like Avodart[R] or Proscar[R]) is that in the presence of prostate cancer, PSA levels don't decrease as much after these drugs are initiated.
If changing medications is not an option, your doctor may prescribe a drug to help control your symptoms, such as an alpha-blocker like Flomax or 5-alpha reductase inhibitor like Avodart, which are used to treat problems caused by prostate enlargement.
For men with significant enlargement, drugs called 5-alpha reductase inhibitors (5-ARIs) are available to shrink the prostate.
Finasteride, a type II 5-alpha reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone, is used for the treatment of androgenic alopecia and has also been shown to decrease the incidence of prostate cancer.
comparison of Finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers.
Laboratory research has shown that mushroom extract can lower levels of 5-alpha reductase, an enzyme linked to male hormones involved in prostate cancer.
The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase.
Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-alpha reductase inhibitor.
Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibennzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose dependent increase of mRNA levels of 5-alpha reductase type 2 in contrast to decrease of androgen receptor in pubertal ventral prostate.

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