MTR

(redirected from 5-Methyltetrahydrofolate-homocysteine methyltransferase)
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MTR

A gene on chromosome 1q43 that encodes an enzyme which transfers a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. It then remethylates the cofactor using methyltetrahydrofolate.

Molecular pathology
Defects in MTRR cause methylcobalamin deficiency type E and folate-sensitive neural tube defects.

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References in periodicals archive ?

Less common causes are MTHFR deficiency, defects of methionine synthase [involving mutations in 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR, also known as CblG)], and defects in vitamin [B.

4] Human genes: MTHFR, methylenetetrahydrofolate reductase (NAD(P)H); MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase; MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; MMADHC, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase.

Teenaged siblings with progressive neurocognitive disease

Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk.

Alcohol, DNA methylation, and cancer

The genes studied were arsenic(+III)methyltransferase (AS3MT), glutathione S-transferase omega 1 (GSTO1), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), methylenetetrahydrofolate reductase (MTHFR), and glutathione S-transferases mu 1 (GSTM1) and theta 1 (GSTT1).

one-carbon metabolism), for example, methylene-tetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), may affect As metabolism.

Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina

5] Human genes: MTHFR, 5,10-methylenetetrahydrofolate reductase (NADPH); MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; NNMT, nicotinamide N-methyltransferase; and CBS, cystathioninebeta-synthase.

Genetic and environmental influences on plasma homocysteine: results from a Danish twin study

METHODS: In 304 Caucasian American NTD families with myelomeningocele or anencephaly, we examined 28 polymorphisms in 11 genes: folate receptor 1, folate receptor 2, solute carrier family 19 member 1, transcobalamin II, methylenetetrahydrofolate dehydrogenase 1, serine hydroxymethyltransferase 1, 5,10-methylenetetrahydrofolate reductase (MTHFR), 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, betaine-homocysteine methyltransferase (BHMT), and cystathionine-beta-synthase.

Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions