Zhang et al., "Functional variants of the
5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: results from an ethnic Han Chinese population," Scientific Reports, vol.
Less common causes are MTHFR deficiency, defects of methionine synthase [involving mutations in 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR, also known as CblG)], and defects in vitamin [B.sub.12] metabolism, such as mutations in methionine synthase reductase [5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR, also known as CblE)] and the CblD-variant-1 defect of the methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria (MMADHC) gene.
[4] Human genes: MTHFR, methylenetetrahydrofolate reductase (NAD(P)H); MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase; MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; MMADHC, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase.
Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and
5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk.
(2.) MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Homo sapiens].
The genes studied were arsenic(+III)methyltransferase (AS3MT), glutathione S-transferase omega 1 (GSTO1),
5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), methylenetetrahydrofolate reductase (MTHFR), and glutathione S-transferases mu 1 (GSTM1) and theta 1 (GSTT1).
[5] Human genes: MTHFR, 5,10-methylenetetrahydrofolate reductase (NADPH); MTR,
5-methyltetrahydrofolate-homocysteine methyltransferase reductase; NNMT, nicotinamide N-methyltransferase; and CBS, cystathioninebeta-synthase.
NM_000355) imports vitamin [B.sub.12], cobalamin, a cofactor for another folate enzyme,
5-methyltetrahydrofolate-homocysteine methyltransferase (MTR; GenBank accession no.