MTR

(redirected from 5-Methyltetrahydrofolate-homocysteine methyltransferase)
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MTR

A gene on chromosome 1q43 that encodes an enzyme which transfers a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. It then remethylates the cofactor using methyltetrahydrofolate.

Molecular pathology
Defects in MTRR cause methylcobalamin deficiency type E and folate-sensitive neural tube defects.
References in periodicals archive ?
Zhang et al., "Functional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: results from an ethnic Han Chinese population," Scientific Reports, vol.
Less common causes are MTHFR deficiency, defects of methionine synthase [involving mutations in 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR, also known as CblG)], and defects in vitamin [B.sub.12] metabolism, such as mutations in methionine synthase reductase [5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR, also known as CblE)] and the CblD-variant-1 defect of the methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria (MMADHC) gene.
[4] Human genes: MTHFR, methylenetetrahydrofolate reductase (NAD(P)H); MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase; MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; MMADHC, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase.
Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk.
The genes studied were arsenic(+III)methyltransferase (AS3MT), glutathione S-transferase omega 1 (GSTO1), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), methylenetetrahydrofolate reductase (MTHFR), and glutathione S-transferases mu 1 (GSTM1) and theta 1 (GSTT1).
[5] Human genes: MTHFR, 5,10-methylenetetrahydrofolate reductase (NADPH); MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; NNMT, nicotinamide N-methyltransferase; and CBS, cystathioninebeta-synthase.
NM_000355) imports vitamin [B.sub.12], cobalamin, a cofactor for another folate enzyme, 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR; GenBank accession no.

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