5-LO

5-LO

Abbreviation for 5-lipooxygenase.

ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
References in periodicals archive ?
Human immunodeficiency virus; H LE, Human leuokocyte elastase; IL, Interleukin: KBA, 11-keto-boswellic acid; LSM, Least squares means; 5-LO.
Its inhibitory effect on 5-LO and the 5-LO/LT pathway is considered to be a novel approach to treat fibrosis.
Taken orally, zileuton inhibits the 5-LO enzyme, which would otherwise catalyze the formation of leukotrienes from arachidonic acid.
NSO produced a concentration dependent inhibition of 5-LO products and 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) production with half maximal effects (IC(50)) at 25+/-1 micro g/ml, respectively 24+/-1 micro g/ml.
Furthermore, 5-LO protein constitutively expressed by OA chondrocytes could be further induced by IL-1[beta] treatment.
In contrast, there is limited information on the ability of other tocopherol isomers to inhibit 5-LO and LT[B.
Cambridge, MA) has patented nucleic acid molecules having a nucleotide sequence of an allelic variant of a 5-LO gene.
The enzyme 5-LO normally plays a key role in initiating the body's breakdown of arachidonic acid -- a fatty acid present in all cells -- into leukotrienes, potent compounds that stimulate inflammation and allergic responses.
In conjunction, MN-001's inhibitory effect on 5-LO and the 5-LO/LT pathway is considered to be a novel approach to treat fibrosis.
The 5-LO/LT pathway has been postulated as a pathogenic factor in fibrosis development and MN-001's inhibitory effect on 5-LO and the 5-LO/LT pathway is considered to be a novel approach to treat fibrosis.
The results demonstrated that ECF administration exerted a powerful anti-inflammatory activity as evidenced by the reduction in the pro-inflammatory markers; IL-1[beta], TNF-[alpha], 5-LO and COX-2.
Full browser ?