Highlights of the oral presentation at ESHG in Gothenburg, Sweden, "HMI-102 Gene Therapy Sustainably Corrects PKU Phenotype in PAHenu2 Mice on Normal Diet," include: Effective, sustained phenotype correction in PAHenu2 murine model on a normal protein diet; Decreased serum Phe, as well as normalization of serum tyrosine levels and a change in coat color, both indicating a restoration of Phe metabolism; and Reduced brain Phe and the neurotransmitter metabolite, 5-HIAA
to normal levels.
El sindrome carcinoide se diagnostica al medir en una orina de 24 horas las concentraciones acido 5-hidroxiindolacetico (5-HIAA
), un metabolito importante de la serotonina (5-HT): valores de 5HIAA dos veces por encima de lo normal son muy sospechosos de sindrome carcinoide (4, 7).
Serotonin decomposes to 5-hydroxyindoleacetic acid (5-HIAA
) by monoamine oxidase which is excreted via urine (9).
The most useful diagnostic test for carcinoid tumor is the 24-hour urinary test for 5-hydroxyindoleacetic acid (5-HIAA
), the metabolic end-product of serotonin.
Thus, plasma chromogranin A and 5-hydroxyindoleacetic acid (5-HIAA
) should be tested in a 24-hour urine sample, and marked octreotide scintigraphy should be performed in the follow-up period (9).
Normally, 1% of dietary tryptophan is converted to serotonin, but in carcinoid, 70% of it is converted to serotonin, which in turn is converted to 5-hydroxyindoleacetic acid (5-HIAA
) in the liver and secreted in urine.
in the cerebrospinal fluid: a biochemical suicide predictor?
They have displayed superior characteristics to poly(vinyl alcohol) (PVA)  carbon nanotube fiber microelectrodes such as higher sensitivities, faster electron transfer kinetics, and a resistance to surface fouling by serotonin and 5hydroxyindoleacetic acid (5-HIAA
Blood 5-hydroxyindole acetate (5-HIAA
), urine 5-HIAA
, and serotonin degradation metabolite levels were elevated at 1121 ng/ml (NR 57-230 ng/ml), 472 ng/ml (NR 1.8-6.1 ng/ml), and 86.9mg/13h (NR 1-6mg/24h), respectively, confirming the diagnosis of carcinoid syndrome.
Follow-up consists of imaging (CT or Magnetic Resonance Imaging) and urinary 5-hydroxyindoleacetic acid (5-HIAA
) every three to four months in the first year.
On the other hand, the raw data on the concentration of 5-HT and 5-HIAA
as well as the expression of genes and proteins, after passing normality and homogeneity of variances tests, were subjected to a two-way ANOVA to determine any significant influences of the two parameters (photoperiod and LPS-treatment), followed by Fisher's least significant difference post-hoc test.
desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA