5-alpha reductase

(redirected from 5 alpha-reductase)

5-alpha reductase

(al'fa re-duk'tās),
Intracellular enzyme that converts testosterone to 5-alpha dihydrotestosterone (DHT). Two distinct isoforms are known in humans and laboratory animals.

5-alpha reductase

An enzyme that converts testosterone to dihydrotestosterone.
See also: reductase
References in periodicals archive ?
Russell, "Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes," Proceedings of the National Academy of Sciences, vol.
Practical approach to steroid 5 alpha-reductase type 2 deficiency.
A 5 alpha-reductase enzyme inhibitor, Dutasterid, works by reducing production of a hormone called dihydrotestosterone (DHT).
The company said dutasteride is a 5 alpha-reductase enzyme inhibitor and works by lowering production of a hormone called dihydrotestosterone (DHT).
First, there are many proposed mechanisms by which isoflavones might induce their therapeutic effects, including inhibition of protein tyrosine kinase [6], binding to estrogen receptors [27], inhibition of ROS production [7, 8], inhibition of angiogenesis [28], modulation of sex steroid binding proteins [29], and inhibition of 5 alpha-reductase activity [6].
PURPOSE: We reviewed the physiological and pathogenic role of dihydrotestosterone (DHT), evidence for the beneficial effects of decreasing DHT through 5 alpha-reductase inhibition and the effects of altering the androgen balance with these agents.
The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases.
Prostatic effects induced in dogs by chronic or acute oral administration of 5 alpha-reductase inhibitors.
Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia.
Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas.