Other etiological diagnosis of our XY DSD patients included hypo gonadotropic hypogonadism (7.9%), primary hypogonadism (7.3%), 5 alpha reductase
deficiency (2.6%), partial gonadal dysgenesis (16.6%), isolated micro penis (12%) which is similar to studies by Atta et al and Erdogan et al18,21.
Notamment la di hydro testosterone qui resulte de la transformation de la testosterone sous l'effet d'une enzyme la 5 Alpha Reductase
. Cette DHT provoque une hypertrophie des glandes sebacees et une involution progressive du bulbe pileux d'ou une diminution de la phase anagene.
Dihydrotestosterone is made from testosterone by 5 alpha reductase
enzyme, which is associated with male pattern baldness and health risks such as prostate growth.
"Young men are being prescribed 5 alpha reductase
inhibitors as hair loss treatments that may negatively impact their sexual life, possibly for a prolonged time after stopping the medication.
Women who suffer from PCOS very frequently have an upregulation in the 5 alpha reductase
pathway--which is seen as an increase in the downstream metabolites driven by this enzyme.
Selective nonsteroidal inhibitors of 5 alpha reductase