dihydrofolate reductase

(redirected from 5,6,7,8-tetrahydrofolate dehydrogenase)

di·hy·dro·fo·late re·duc·tase (DHFR),

(dī-hī'drō-fō'lāt rē-dŭk'tās), [MIM*126060]
An enzyme reversibly oxidizing tetrahydrofolate to 7,8-dihydrofolate with NADP+. A crucial enzyme in one-carbon metabolism; used as a marker of drug resistance to methotrexate.
Synonym(s): 5, 6, 7, 8-tetrahydrofolate dehydrogenase

dihydrofolate reductase

An enzyme necessary for the synthesis of the purines of DNA.