Estandia-Ortega B, Velazquez-Aragon J, Alcantara-Ortigoza M, Reyna-Fabian M, Villagomez-Martinez S, Gonzalez-Del Angel A (2014) 5,10-Methylenetetrahydrofolate reductase
single nucleotide polymorphisms and gene-environment interaction analysis in non-syndromic cleft lip/palate.
Adverse effect of nitrous oxide in a child with 5,10-methylenetetrahydrofolate reductase
Iascone et al., "Association between 5,10-methylenetetrahydrofolate reductase
C677T and A1298C polymorphisms and conotruncal heart defects," Clinical Chemistry and Laboratory Medicine, vol.
Molecular biology of 5,10-methylenetetrahydrofolate reductase
. J Nephrol 2000;13(1):20-33.
BACKGROUND AND PURPOSE: 5,10-Methylenetetrahydrofolate reductase
(MTHFR) is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF).
(MTHFR) 677C-->T and 1298A-->C mutations are associated with DNA hypomethylation.
polymorphisms and the risk of pancreatic cancer.
Another concern about folic acid is that some people, such as the 5% to 15% of the population that is homozygous for the 677C [right arrow] T polymorphism of the 5,10-methylenetetrahydrofolate reductase
(MTHFR) gene, might have difficulty converting folic acid to its biologically active form, and therefore might not benefit sufficiently from folic acid supplementation.
deficiency with progressive polyneuropathy in an infant.
Mlinaric-Rascan, "5,10-methylenetetrahydrofolate reductase
(MTHFR) low activity genotypes reduce the risk of relapse-related acute lymphoblastic leukemia (ALL)," Leukemia Research, vol.
Relationship between 5,10-methylenetetrahydrofolate reductase
C677T gene polymorphism and methotrexate related toxicity in patients with autoimmune diseases receiving folic acid supplementation.
 Engbersen AMT, Franken DG, Boers GHJ, et al: Thermolabile 5,10-methylenetetrahydrofolate reductase
as a cause of mild hyperhomocysteinemia: Am J Hum Genet 1995; 56: 142-150.