5'-nucleotidase

5'-nucleotidase

An enzyme present in the serum in abnormal amounts in diseases that affect the liver or obstruct the biliary tree.
Synonym: 5'- Ntase.
References in periodicals archive ?
CD39 can also convert the latter molecule into AMP, fully dephosphorylated to ADO by the 5'-nucleotidase (5'-NT) CD73 [7].
Rosa et al., "Piracetam prevents scopolamine-induced memory impairment and decrease of NTPDase, 5'-nucleotidase and adenosine deaminase activities," Neurochemical Research, vol.
However, ratio of dCK and cytosolic 5'-nucleotidase II (cN-II), which inactivates Ara-C by dephosphorylation, has been shown to predict ara-C sensitivity.29
Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro.
In addition, four dihydroorotase genes, two dihydroorotate dehydrogenase genes, three uridine monophosphate synthetase genes, two 5'-nucleotidase genes, one uridine nucleosidase gene, one udk gene, two UMP-CMP kinase genes, one ndk gene, one apyrase gene, one ITPA gene, one CTP synthase gene, and one cdd gene were successfully cloned (Figure S4, Supporting Information).
Lipid peroxidation is followed by loss of structural integrity of plasma membranes thereby releasing the membrane associated enzymes like Adenosine deaminase and 5'-nucleotidase into the circulation.
5'-nucleotidase is an intrinsic membrane glycoprotein, present as an ectoenzyme in a wide variety of mammalian cells and it hydrolyzes extracellular AMP to adenosine and represents the major control point for extracellular adenosine levels and is a regulator of the adenosine signaling pathway.
In order to evaluate the effect of the surface modification on 5'-nucleotidase (5eNT) separation, magnetite with no modification (M), silica-magnetite (MS), silica-aminosilane-magnetite (MSA), silica-amino silane-ScFv antibody-magnetite (MSACF), and silica-aminosilane-anti-CD73 antibody (MSA-CD73) were tested.
Agapidou et al.'s case of pyrimidine 5'-nucleotidase deficiency and heterozygous [alpha]-thalassemia was an interesting co-existence (1).
Moreover, hypothyroidism increased the expression of NTPDase1 and 5'-nucleotidase, whereas hyperthyroidism decreased the expression of this enzyme in hippocampus of adult rats.
In the second assay, 5'-Nucleotidase activity was determined using the [[sup.3]H]AMP as described by Avruch and Wallach [7] and modified by Newby et al.