4-dinitrophenol


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Sports medicine—Body-building A potent non-selective inhibitor of oxidative phosphorylation, which results in increased metabolism and increased body temperature, and has been used illegally for weight control
Toxicology Any of a family of compounds used in weed control and, at one time, for weight control, which may cause death due to the uncoupling of mitochondrial oxidative phosphorylation, resulting in increased body temperature, rapid breathing, tachycardia, nausea, flushed skin, cyanosis, collapse, coma; dinitrophenol poisoning causes rapid death or recovery in 24 hours
Management Ice baths, O2, correct fluid and electrolyte imbalances
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Hess TF, Silverstein J, Schmidt SK (1993) Effect of glucose on 2, 4-dinitrophenol degradation kinetics in sequencing batch reactors.
Salinity and temperature effects on chronic toxicity of 2, 4-dinitrophenol and 4-nitrophenol to sheepshead minnows (Cyprinodon variegatus).
Each group was treated with a different concentration of 2, 4-dinitrophenol in seawater (0 [micro]M [control], 15 [micro]M, and 30 [micro]M) for 4 h per day.
The yellow odourless drug, thought to boost metabolism, is sold mainly to bodybuilders over the internet under a number of different names but contains 2, 4-Dinitrophenol.