4-AP


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4-AP

4-aminopyridine.
References in periodicals archive ?
Effect of glibenclamide, 4-AP, TEA, and apamin plus charybdotoxin on the vasorelaxation induced by clobenzorex in phenylephrine-precontracted rat aortic rings
The hybrid materials were used in different amounts and at different temperature conditions as a catalyst for the reduction of 4-NP to 4-AP.
While the toxic, epileptogenic side effects resulting from 4-AP likely arise from the indiscriminate blockade of various CNS [K.
While further studies are needed before this drug can go to the Food and Drug Administration for approval, the current study concluded that 4-AP is safe.
For example, the organization supported preliminary basic-science research on 4-AP and some of the initial studies in humans; most recently, PVA provided start-up, "seed" investment funds for Acorda, which has raised the extensive funding needed to carry out the FDA-required regulatory studies.
Our findings that the potassium channel ionophore nigericin inhibits settlement and metamorphosis induced by JH III and that 4-AP can directly stimulate settlement and metamorphosis provide evidence that JH stimulates settlement and metamorphosis through the closure of potassium channels.
At present, 4-AP is available from Acorda Therapeutics/Elan Pharmaceuticals for patients enrolled in clinical trials, or through compounding by local pharmacies for individuals not in trials.
The experimental drug 4-AP (4-aminopyridine) has been tested as a remedy but more research work is needed (see page 10).
Although 4-AP does not replace the myelin, it can interact with membrane channels the same way myelin does to increase the speed of nerve signals.
4-AP is now in late-stage clinical trials for MS, and preliminary clinical studies in SCI have yielded promising results.
First tested in people with multiple sclerosis (MS), 4-AP enhanced some neurological functions in some subjects.
Because demyelination is the key feature of multiple sclerosis (MS), 4-AP has already reached advanced clinical trials for people with MS.