adenosine 3'-phosphate 5'-phosphosulfate

(redirected from 3-phosphoadenosine 5-phosphosulfate)

a·den·o·sine 3'-phos·phate 5'-phos·pho·sul·fate (PAPS),

(ă-den'ō-sēn fos'fāt fos'fō-sūl'fāt),
An intermediate in the formation of urinary ethereal sulfates, notable for containing a "high-energy" sulfate bond; the 3'-OH of adenosine is replaced by -OPO3H2 and the 5'-OH by -OP(O2H)-OSO3H.
Synonym(s): active sulfate
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The synthesis of PAPS (3-phosphoadenosine 5-phosphosulfate) -a sulfate donor - is catalyzed by two isoenzymes (PAPS synthase1 and PAPS synthase 2).