The 3-nitropropionic acid
(3NPA) is a toxin that is naturally present in leguminous plants used to feed animals and can poison grazing livestock .
In a rat model study for Huntington's disease, researchers investigated the protective effects of L-theanine against 3-nitropropionic acid
Of additional interest are the findings that a combined oral supplementation of quercetin and fish oil enhanced neuroprotection in rats exposed to 3-nitropropionic acid
or chronically treated with the insecticide rotenone [51, 52].
Quercetin supplementation has also been shown to improving mitochondrial dysfunctions induced by the toxin 3-nitropropionic acid
Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid
induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice.
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid
Further evidence that dietary intake of BM leaf powder confers the prepubertal brain with additional capacity to cope up with neurotoxic prooxidants was obtained by exposing cortical/cerebellar synaptosomes of normal and BM fed mice to 3-nitropropionic acid
L-carnitine has also protective influence on the 3-nitropropionic acid
(3-NPA) induced neurotoxicity which increased by hypothermia (Z.
Antioxidant effects of taurine, vitamin C, and vitamin E on oxidative oxidative damage in hippocampus caused by the administration of 3-nitropropionic acid
Neuronal degeneration can be caused by the mitochondrial toxin 3-nitropropionic acid
(3-NPA) and produce anatomical changes similar to those in Huntington's disease.
The 12 articles here address sources of exposure ranging from recreational drugs to industrial chemicals, including MDMA (Ecstasy) and its effects on serotonin, certain pesticides and chemical warfare agents and their ability to induce muscle paralysis, local anesthetics and their possible link to ischemic injury or Alzheimer's Disease, alcohol and peripheral neuropathy, the deposition of amyloid peptides and Alzheimer's Disease, 3-nitropropionic acid
and symptoms similar to Huntington's Chorea, antineoplastic drugs and damage to the peripheral nervous system, side effects of chemotherapy, cefepime-induced encephalopathy, simulation of Parkinson's Disease, and the effects of overexposure to manganese.
To study the effect of metabolic disorder at a cellular level, we have utilized 3-nitropropionic acid
(3NP) to induce energy impairment and assess the metabolic response of two age groups to such stress.