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, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells," Journal of Cellular Physiology, vol.
(3-MC/MCA) is an important carcinogen and is often used by researchers to induce tumors in rodents.
There are exceptions, such as arsenic in people and 3-methylcholanthrene
and antramine in rats.
In mice, this was demonstrated by the specific loss of CTNNB1 that encodes [beta]-catenin and leads to a decrease of mCyp1a1 induction by AHR agonists such as 3-methylcholanthrene
(3-MC), [beta]-naphthoflavone ([beta]-NF), and butylated hydroxyanisole.
(2000) Distribution and inducibility by 3-methylcholanthrene
of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.
The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-pdioxin and 3-methylcholanthrene
regulate distinct genetic networks.
Poland, "An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene
and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin," Journal of Pharmacology and Experimental Therapeutics, vol.
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene
and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Hari Kumar, tested the medicines' ability to inhibit liver cancer in rats fed N'-nitrosodiethylamine (NDEA) and sarcoma in mice injected with 3-methylcholanthrene
induces differential recruitment of aryl hydrocarbon receptor to human promoters," Toxicological Sciences, vol.117, no.1, pp.1-3,2010.
Effect of interleukin-12 on tumor induction by 3-methylcholanthrene
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Regulation of cyto-chrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene
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