3-methylcholanthrene

3-meth·yl·chol·an·threne

(meth'il-kōl-an'thrēn),
A highly carcinogenic hydrocarbon that can be formed chemically from deoxycholic or cholic acids, or from cholesterol; it induces the synthesis of cytochrome P-450 mRNA; the choice between 3- or 20- for the methyl group depends upon whether hydrocarbon (inner) or steroid (outer) numbering is chosen; in the latter case, the formal relationship to the cholic acids and cholesterol is clear.
References in periodicals archive ?
Juan, "Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells," Journal of Cellular Physiology, vol.
3-Methylcholanthrene (3-MC/MCA) is an important carcinogen and is often used by researchers to induce tumors in rodents.
There are exceptions, such as arsenic in people and 3-methylcholanthrene and antramine in rats.
In mice, this was demonstrated by the specific loss of CTNNB1 that encodes [beta]-catenin and leads to a decrease of mCyp1a1 induction by AHR agonists such as 3-methylcholanthrene (3-MC), [beta]-naphthoflavone ([beta]-NF), and butylated hydroxyanisole.
(2000) Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.
The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-pdioxin and 3-methylcholanthrene regulate distinct genetic networks.
Poland, "An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin," Journal of Pharmacology and Experimental Therapeutics, vol.
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Hari Kumar, tested the medicines' ability to inhibit liver cancer in rats fed N'-nitrosodiethylamine (NDEA) and sarcoma in mice injected with 3-methylcholanthrene (3-MC).
Safe, "3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters," Toxicological Sciences, vol.117, no.1, pp.1-3,2010.
Effect of interleukin-12 on tumor induction by 3-methylcholanthrene. Proc Natl Acad Sci USA 1996;93:11798-801.
Regulation of cyto-chrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. Biochem Pharmacol 56:599-612.
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