A highly carcinogenic hydrocarbon that can be formed chemically from deoxycholic or cholic acids, or from cholesterol; it induces the synthesis of cytochrome P-450 mRNA; the choice between 3- or 20- for the methyl group depends upon whether hydrocarbon (inner) or steroid (outer) numbering is chosen; in the latter case, the formal relationship to the cholic acids and cholesterol is clear.
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Hari Kumar, tested the medicines' ability to inhibit liver cancer in rats fed N'-nitrosodiethylamine (NDEA) and sarcoma in mice injected with 3-methylcholanthrene (3-MC).
Additional control groups received one of the following treatments: saline (control); 3-methylcholanthrene (25 mg/kg, i.
Enhancing effect of quercetin on 3-methylcholanthrene carcinogenesis in C57B1/6 mice.
Studies show cancer-triggers such as 3-methylcholanthrene, found in cigarette smoke, are also concentrated in prostate fluid.
1980) reported that addition of acetone extract of vegetables to the Salmonella mutagenicity assay mixture of benzo(a)pyrene (BaP) and 3-methylcholanthrene, reduced the number of revertant colonies.
Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene.
Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.
Similarly, the AhR ligand 3-methylcholanthrene increases PPAR-[alpha] expression in C57B1/6J mice (Kawano et al.
Main substance classes are polycyclic aromatic hydrocarbons (PAHs), such as 3-methylcholanthrene (3-MC) and benzo(a) pyrene [B(a)P], dioxins such as 2,3,7,8-tet-rachlorodibenzo-p-dioxin (TCDD), and polychlorinated biphenyls (PCBs).
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachloro-dibenzo-p-dioxin or 3-methylcholanthrene.
Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetra-chlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.
Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (soup): cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450.
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