3-methylcholanthrene

3-meth·yl·chol·an·threne

(meth'il-kōl-an'thrēn),

A highly carcinogenic hydrocarbon that can be formed chemically from deoxycholic or cholic acids, or from cholesterol; it induces the synthesis of cytochrome P-450 mRNA; the choice between 3- or 20- for the methyl group depends upon whether hydrocarbon (inner) or steroid (outer) numbering is chosen; in the latter case, the formal relationship to the cholic acids and cholesterol is clear.

References in periodicals archive ?

2000) Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.

Anticancer activities of resveratrol in colorectal cancer

The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-pdioxin and 3-methylcholanthrene regulate distinct genetic networks.

Systems toxicology of male reproductive development: profiling 774 chemicals for molecular targets and adverse outcomes

Poland, "An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin," Journal of Pharmacology and Experimental Therapeutics, vol.

Erectile Dysfunction Drugs Changed the Protein Expressions and Activities of Drug-Metabolising Enzymes in the Liver of Male Rats

Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.

Methylated TIMP-3 DNA in Body Fluids Is an Independent Prognostic Factor for Gastric Cancer

Hari Kumar, tested the medicines' ability to inhibit liver cancer in rats fed N'-nitrosodiethylamine (NDEA) and sarcoma in mice injected with 3-methylcholanthrene (3-MC).

Shorts

Effect of interleukin-12 on tumor induction by 3-methylcholanthrene.

Effect of acute maximal exercise on circulating levels of interleukin-12 during Ramadan fasting

Regulation of cyto-chrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.

Mudancas induzidas por dioxina na contagem epididimal de esperma e espermatogenese

Additional control groups received one of the following treatments: saline (control); 3-methylcholanthrene (25 mg/kg, i.

Effects of major tanshinones isolated from Danshen (salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates

Enhancing effect of quercetin on 3-methylcholanthrene carcinogenesis in C57B1/6 mice.

Ethnomedical and veterinary uses of Tephrosia vogelii Hook F (Fabaceae): a review

Studies show cancer-triggers such as 3-methylcholanthrene, found in cigarette smoke, are also concentrated in prostate fluid.

Dr Miriam: Seeds of doubt over my sex life; LETTER OF THE DAY

The 25 chemicals with a score of 18 are: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, 7, 12-dimethylbenz(a) anthracene, Aldrin, benzo(a) anthracene, benzo(a) pyrene, benzo(b) fluoranthene, benzo(rst) pentaphene, Chlordane, p,p'-dichloro-diphenyl-dichloro-ethane, p,p'-dichloro-diphenyl-dichloro-ethylene, p,p'-dichloro-diphenyl-trichloro-ethane, dibenzo(a,h) anthracene, Dieldrin, Endrin, Heptachlor, hexachlorobenzene, hexachlorocyclopentadiene, hexachloraphene, kepone, mercury, Mirex, pentachlorobenzene, polychlorinated biphenyls, and toxaphene.

Regulating Chemical Emissions with Risk-Based Environmental Taxation

Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout.

Testing models of migration and isolation among populations of chinook salmon (Oncorhynchus tschawytscha)