An antimetabolite of nicotinamide that produces symptoms of nicotinamide deficiency in mice; a neurotoxin that damages hypothalamus, brainstem, and basal ganglia.
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Studies in adult rats have demonstrated that a few days after a subtotal lesion of the inferior olivary neurons induced by 3-acetylpyridine, the surviving CFs are able to sprout and reinnervate the denervated PCs [93, 94] while a large number of new spines emerge from the PC's proximal dendritic domain accompanied by sprouting of nearby located PFs [95, 96].
Based on this principle, this assay could detect malarial pLDH enzyme which utilized 3-acetylpyridine nicotinamide adenine dinucleotide (APAD) as NAD and nicotinamide adenine dinucleotide analogue, whereas erythrocyte LDH could not [45, 46].
Paul, "Corrosion inhibition investigations of 3-acetylpyridine semicarbazone on carbon steel in hydrochloric acid medium," Research on Chemical Intermediates, vol.