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β-hy·drox·y-β-meth·yl·glu·tar·yl-CoA (HMG-CoA),

A key intermediate in the synthesis of ketone bodies, of steroids, and of farnesyl and geranyl derivatives.
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HMGCS2: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase 2 [beta]HB: [beta]-Hydroxybutyrate HDAC: Histone deacetylase SIRT3: Sirtuin 3 MnSOD: Manganese superoxide dismutase FOXO3a: Forkhead box O3a GTPs: Green tea polyphenols CON: Control HFD: High-fat diet Nampt: Nicotinamide phosphoribosyltransferase 4-HNE: 4-Hydroxy-2-nonenal KB: Ketone body CR: Calorie restriction ROS: Reactive oxygen species NAG: N-Acetyl-[beta]-D-glucosaminidase TC: Total cholesterol TG: Triglycerides HDL-C: High-density lipoprotein-cholesterol LDL-C: Low-density lipoprotein-cholesterol.
Leopoldini, M., Malaj, N., Toscano, M., Sindona, G., Russo, N., 2010, On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme.
3-Hydroxy-3-methylglutaryl-CoA synthase: participation of invariant acidic residues in formation of the acetyl-S-enzyme reaction intermediate.
The primary goal was to inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) responsible for cholesterol biosynthesis in the body.
This question is particularly relevant as the expression of the low-density lipoprotein receptor that is responsible for the intracellular uptake of cholesterol is regulated by mTOR,[sup.56] an active signaling pathway in RCC.[sup.57] Statins are synthetic agents that inhibit the rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl-CoA reductase, thereby inhibiting cholesterol biosynthesis.[sup.58] Recently, it has been suggested that statins may have activity against RCC.
Effect of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors on the concentration of insulin-like growth factor-1 (IGF-1) in hypercholesterolemic patients 2009 Jul - Aug; 61 (4): 654-64.
Statins are inhibitors of the rate-limiting enzyme, 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, in cholesterol biosynthesis.
HMG-CoA reductase (or 3-hydroxy-3-methylglutaryl-CoA reductase or HMGR) is the rate controlling enzyme (EC of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.
Genes spotted multiple times on different parts of the array include 3-hydroxy-3-methylglutaryl-CoA reductase, glycosylate reductase, choriogenin 2, a clone that shares homology to Unknown protein (GenBank accession no.
3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency(*)--If this disorder is untreated, it is likely to result in death during childhood.