HMGCS2: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA
(HMG-CoA) synthase 2 [beta]HB: [beta]-Hydroxybutyrate HDAC: Histone deacetylase SIRT3: Sirtuin 3 MnSOD: Manganese superoxide dismutase FOXO3a: Forkhead box O3a GTPs: Green tea polyphenols CON: Control HFD: High-fat diet Nampt: Nicotinamide phosphoribosyltransferase 4-HNE: 4-Hydroxy-2-nonenal KB: Ketone body CR: Calorie restriction ROS: Reactive oxygen species NAG: N-Acetyl-[beta]-D-glucosaminidase TC: Total cholesterol TG: Triglycerides HDL-C: High-density lipoprotein-cholesterol LDL-C: Low-density lipoprotein-cholesterol.
Leopoldini, M., Malaj, N., Toscano, M., Sindona, G., Russo, N., 2010, On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA
reductase (HMGR) enzyme.
synthase: participation of invariant acidic residues in formation of the acetyl-S-enzyme reaction intermediate.
The primary goal was to inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA
reductase (HMGR) responsible for cholesterol biosynthesis in the body.
Statins decrease cholesterol synthesis by inhibiting the rate-limiting enzyme, 3-hydroxy-3-methylglutaryl-CoA
(HMG-CoA) reductase, involved in the mevalonate and cholesterol synthesis (Riganti, et al.
This question is particularly relevant as the expression of the low-density lipoprotein receptor that is responsible for the intracellular uptake of cholesterol is regulated by mTOR,[sup.56] an active signaling pathway in RCC.[sup.57] Statins are synthetic agents that inhibit the rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl-CoA
reductase, thereby inhibiting cholesterol biosynthesis.[sup.58] Recently, it has been suggested that statins may have activity against RCC.
Effect of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA
) reductase inhibitors on the concentration of insulin-like growth factor-1 (IGF-1) in hypercholesterolemic patients 2009 Jul - Aug; 61 (4): 654-64.
Statins are inhibitors of the rate-limiting enzyme, 3-hydroxy-3-methylglutaryl-CoA
(HMG-CoA) reductase, in cholesterol biosynthesis.
HMG-CoA reductase (or 3-hydroxy-3-methylglutaryl-CoA
reductase or HMGR) is the rate controlling enzyme (EC 126.96.36.199) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.
organic acidurias such as glutaryl-CoA dehydrogenase, 3-hydroxy-3-methylglutaryl-CoA
lyase, [beta]-ketothiolase, Propionyl-CoA carboxylase, Methylmalonyl-CoA mutase, and Isovaleryl-CoA dehydrogenase) (Vreken et al., 1999).
Genes spotted multiple times on different parts of the array include 3-hydroxy-3-methylglutaryl-CoA
reductase, glycosylate reductase, choriogenin 2, a clone that shares homology to Unknown protein (GenBank accession no.
Lyase Deficiency(*)--If this disorder is untreated, it is likely to result in death during childhood.