adenosine 3'-phosphate 5'-phosphosulfate

(redirected from 3'-phosphoadenosine 5'-phosphosulfate)

a·den·o·sine 3'-phos·phate 5'-phos·pho·sul·fate (PAPS),

(ă-den'ō-sēn fos'fāt fos'fō-sūl'fāt),
An intermediate in the formation of urinary ethereal sulfates, notable for containing a "high-energy" sulfate bond; the 3'-OH of adenosine is replaced by -OPO3H2 and the 5'-OH by -OP(O2H)-OSO3H.
Synonym(s): active sulfate
Farlex Partner Medical Dictionary © Farlex 2012
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References in periodicals archive ?
Estrogen sulfotransferase (EST) is a cytosolic sulfotransferase that transfers a sulfuryl group from the ubiquitous sulfate donor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the 3-hydroxyl on 17[beta]-estradiol (E2).
The co-substrate and active sulfate donor was radiolabeled 3'-phosphoadenosine 5'-phosphosulfate (([sup.35]S)PAPS) 7[Mu]M (2145 dpm/pmol) in the presence of pyrophosphatase and sulfatase inhibitors and 10 mM [Mg.sup.2+] buffered at pH 6.3.